GWEIS analyses
All the significant G×E interactions
(P < 5.00 × 10−8) and suggestive
significant G×E interactions
(P < 1.00 × 10−5) were shown in
Supplemental Table 1-2. For left HGS, we detected 6 significant G×E
interactions of C-section, including ADGRV1 gene (rs77788156,P = 9.13 × 10−9; rs114592446,P = 2.16 × 10−8), POLR3G gene (rs112985393,P = 9.29 × 10−9), and WASL gene (rs62472074,P = 4.74 × 10−8) (Supplemental Table 1). For
right HGS, 32 significant G×E interactions of C-section were detected,
including APBB2 gene (rs62409974,P = 2.70 × 10−8; rs62410025,P = 2.89 × 10−8; rs62409998,P = 2.93 × 10−8), and CRPPA gene (rs148803065,P = 1.32 × 10−8). Several SNPs nearing CRPPA
gene were also showed suggestive significant interactions with C-section
(Supplemental Table 2). Interestingly, Comparing the analyses results of
left HGS and right HGS, identified suggestive significant interactions
between CLEC16A gene and C-section, including rs80001954
(Pright = 5.21 × 10−8,Pleft = 1.22 × 10−7);
rs117658390
(Pright = 5.43 × 10−8,Pleft = 1.09 × 10−7)
and rs79479146
(Pright = 5.45 × 10−8,Pleft = 1.22 × 10−7)
(Supplemental Table 3).