GWEIS analyses
All the significant G×E interactions (P < 5.00 × 10−8) and suggestive significant G×E interactions (P < 1.00 × 10−5) were shown in Supplemental Table 1-2. For left HGS, we detected 6 significant G×E interactions of C-section, including ADGRV1 gene (rs77788156,P  = 9.13 × 10−9; rs114592446,P  = 2.16 × 10−8), POLR3G gene (rs112985393,P  = 9.29 × 10−9), and WASL gene (rs62472074,P  = 4.74 × 10−8) (Supplemental Table 1). For right HGS, 32 significant G×E interactions of C-section were detected, including APBB2 gene (rs62409974,P  = 2.70 × 10−8; rs62410025,P  = 2.89 × 10−8; rs62409998,P  = 2.93 × 10−8), and CRPPA gene (rs148803065,P  = 1.32 × 10−8). Several SNPs nearing CRPPA gene were also showed suggestive significant interactions with C-section (Supplemental Table 2). Interestingly, Comparing the analyses results of left HGS and right HGS, identified suggestive significant interactions between CLEC16A gene and C-section, including rs80001954 (Pright = 5.21 × 10−8,Pleft = 1.22 × 10−7); rs117658390 (Pright  = 5.43 × 10−8,Pleft = 1.09 × 10−7) and rs79479146 (Pright  = 5.45 × 10−8,Pleft = 1.22 × 10−7) (Supplemental Table 3).