Gene set enrichment analysis
FUMA platform (http://fuma.ctglab.nl/) was used to study the enrichment analysis of the obtained genes. FUMA is a web-based comprehensive platform that can utilize a variety of biological resource information to annotate the function, gene priority and interactive visualization of GWAS results 22. Genes with genome-wide significant interaction effects or suggestively significant interaction effects on left HGS or on right HGS identified in GWEIS were used as input. GENE2FUNC function was used to obtain related gene ontology (GO). Enrichment of prioritized genes is tested using the hypergeometric test against gene sets obtained from MsigDB 23. A total of 5817 GO terms were included in the analyses, in which 4436 for GO biological process, 580 for GO cellular component and 901 for GO molecular function. Benjamini-hochberg method was performed to correct multiple tests.