Serum coagulation levels for predicting initial IVIG
resistance
As shown in Table 1, there were no significant differences in age, sex,
the day of illness before IVIG treatment, sampling day of illness, and
typical clinical manifestations between the initial IVIG-responsive and
IVIG-resistant groups. As for other cardiac complications, the
percentage of patients with cardiac enlargement and pericardial effusion
was found to be significantly higher in the initial IVIG-resistant group
(p=0.003 and p=0.016, respectively). Initial IVIG-resistant patients had
much higher incidence of CALs, with substantial higher level of serum
C-reactive protein (CRP),
neutrophil-lymphocyte ratio (NLR),
serum total bilirubin (TB),
serum alanine aminotransferase
(ALT),
creatinine,
urea nitrogen, but with lower
hemoglobin,
platelet count, albumin, sodium,
potassium before the initial IVIG treatment (all P < 0.005).
No significant differences were found in the white blood cell count,
erythrocyte sedimentation rate, and aspartate aminotransferase between
the two groups.
The effect of KD on the coagulation system was evaluated by assessing
the coagulation profiles of initial IVIG-responsive and IVIG-resistant
subjects. The PT (14.3 [13.6-15.5] s vs. 13.8 [13-14.4] s,
p=0.005) and APTT (35.3 [31.9-44.7] s vs. 34.2 [30.7-38.1] s,
p=0.006) were significantly longer in the initial IVIG-resistant group,
with significantly higher D-dimer levels (2.1 [1.20-2.82] mg/l vs.
1.2 [0.8-2.07] mg/l, p=0.020) as well as ATIII activity (81%
[65-88%] vs. 89% [81-100%], p<0.001) (Table 1).