Key points:
- Due to chronic nature of cystic fibrosis, the patients frequently
exposed not only to antibiotics but also NSAIDs, proton pump
inhibitors and others.
- Numerous and long-term use of multiple drugs during management of
cystic fibrosis may contribute to tolerance development and protect
patients from actual drug allergy.
- Non-beta lactam antibiotic hypersensitivity is important in patients
with cystic fibrosis which requires diagnostic work up.