Methods
We included children with cystic fibrosis followed at the Hacettepe
University Pediatric Pulmonology Department. The study was performed in
accordance with the protocol approved by the local ethical committee
(Hacettepe University, GO 15/811), and all parents/guardians gave
written informed consent.
We carried out a self-designed questionnaire survey concerning
demographic factors [age at CF diagnosis, Cystic Fibrosis
Transmembrane Conductance Regulator (CFTR) mutation results years of
follow up, history of allergic diseases and DHRs, detailed data about
chronically used medications (the onset and duration of use,
administration route)] and reviewed medical records to note the
hospitalizations due to lower respiratory tract infections and/or number
of parenteral AB used within last year, average annual use of oral
antibiotics, complications related with CF and chronic colonizations
(Pseudomonas aeruginosa, Staphylococcus aureus ). In case of
history or new occurrence of any suspicious DHR, the patients were
evaluated by the pediatric allergy department.