Impact Statement
We showed for the first time that
barley allergy associated with wheat allergy is caused by
cross-reactivity from wheat. In this study, we found that wheat OIT
increased the symptom-inducing threshold of barley allergy. Although the
cross-reactive proteins between wheat and barley were not identified
from the results of immunoblotting inhibition, it is expected that the
mechanisms of cross-antigenicity of wheat and barley will be clarified
in the future.