The second barley-OFC after OIT for wheat
Among nine patients with positive results to the first barley-OFCs, two patients enrolled slow OIT while seven enrolled rush OIT for wheat (Table 2). Wheat-OFCs results before OIT are shown in Table S1. All patients achieved desensitized status to a daily amount of wheat products (equivalent to 2,000 mg wheat protein) within three years.
The second barley-OFC was performed at a median of 2 (range: 1.1–5.5) years after the first barley-OFCs (Table 2). The results were negative for all nine patients. The median amount of desensitized wheat protein was 5,580 mg (range: 2046–7800) at the second barley-OFC. The sIgE titers to omega-5 gliadin after wheat OIT significantly decreased compared to before OIT (Table 3). On the other hand, the change in barley-sIgE was not uniform (reduction: 5 patients, elevation: 2 patients, no data: 2 patients).