-Predictors for in-hospital mortality
Age (p<0.001), renal failure (p<0.001), redo surgery (p<0.001), COPD (p=0.002), female sex(p=0.006), and MetS (p=0.003) were independent predictors for in-hospital mortality (full ORs reported in Supplementary Table 4 ). There was a statistically significant interaction between SAVR, TAVR and MetS (p for interaction= 0.004 and 0.003) suggesting lower association to mortality in these cohorts compared to the MVS cohort (reference level). Notably, sensitivity analysis showed BMI (continuous variable) as inversely associated to mortality (p=0.02), while no significant association with mortality, insulin resistance, atherogenic dyslipidaemia and systemic hypertension (Supplementary Table 5) .