Table 2. Baseline patients’ characteristics and peri-operative outcomes, SAVR cohort
Overall N=8340 No-MetS N=7453 Mets N=887
p
Age, y/o, (mean (SD)) 71.2 (11.6) 71 (12) 73.5 (7.6) <0.001
BMI kg/m2 (mean (SD)) 27.4 (4.5) 27 (4.3) 30.2 (5.1) <0.001
BMI ≥ 30 kg/m2 1391 (16.7) 1015 (13.6) 376 (42.4) <0.001
Sex male, n (%) 4516 (54.1) 4088 (54.9) 428 (48.3) <0.001
Diabetes, n (%) <0.001
IDDM, n (%) 249 (3) 71 (1) 178 (20.1)
NIDDM, n (%) 780 (9.4) 228 (3.1) 552 (62.2)
IGT/IFT, n (%) 243 (2.9) 86 (1.2) 157 (17.7)
Atherogenic dyslipidemia, n (%) 3419 (41) 2616 (35.1) 803 (90.5) <0.001
Systemic hypertension, n (%) 5085 (61) 4215 (56.6) 870 (98.1) <0.001
Creatinine > 1.2 mg/dl 253 (3) 196 (2.6) 57 (6.4) <0.001
COPD, n (%) 537 (6.4) 444 (6) 93 (10.5) <0.001
LVEF, %, (mean (SD)) 55 (8.2) 55 (8.2) 54.8 (7.9) 0.48
Peripheral vascular disease, n (%) 508 (6.1) 404 (5.4) 104 (11.7) <0.001
Previous CABG/PCI 520 (6.2) 419 (5.6) 101 (11.3) <0.001
Current/ ex-smokers, n (%) 2203 (26.4) 1861 (24.9) 342 (38.5) <0.001
Redo surgery, n (%) 533 (6.4) 465 (6.2) 68 (7.7) 0.11
AF§, n (%) 696 (8.3) 587 (7.9) 109 (12.3) <0.001
Minimally invasive, n (%) 4205 (50.4) 4270 (51.1) 724 (47.2) 0.20
CPB time, min, median (IQR) 76 (34) 75 (35) 79 (33) 0.005
Cross clamp time, min, median (IQR) 60 (29) 60 (28) 62 (27) 0.007
Ventilation time, hours, median (IQR) 7 (5) 7 (6) 7 (5) 0.26
RBC transfused, n (%) 2424 (29.1) 2067 (27.7) 357 (40.2) <0.001
Invalidating stroke, n (%) 34 (0.4) 29 (0.4) 5 (0.6) 0.99
Renal failure, n (%) 509 (616) 419 (5.6) 90 (10.1) <0.001
ICU LOS, days, median (IQR) 2 (1) 2 (1) 2 (2) 0.007
Post-operative LOS, days, median (IQR) 10 (6) 10 (5) 10 (6) 0.002
In-hospital mortality, n (%) 172 (2.1) 156 (2.1) 16 (1.8) 0.65
Data are reported as number or frequency or mean and standard deviation (SD) or median and interquartile range (IQR). AF: Atrial fibrillation. BMI: Body mass index. COPD: Chronic obstructive pulmonary disease. CPB: Cardiopulmonary bypass. ICU: Intensive care unit. IDDM: Insulin dependent diabetes mellitus. IGT: Impaired glucose tolerance. IFT: Impaired fasting glucose. LVEF: Left ventricle ejection function. MetS: Metabolic syndrome. NIDDM: non-insulin dependent diabetes mellitus. RBC: Red blood cells. SAVR: Surgical aortic valve replacement. Refers to at least 2 units of RBC transfused § Include paroxysmal, persistent and permanent AF. Data are reported as number or frequency or mean and standard deviation (SD) or median and interquartile range (IQR). AF: Atrial fibrillation. BMI: Body mass index. COPD: Chronic obstructive pulmonary disease. CPB: Cardiopulmonary bypass. ICU: Intensive care unit. IDDM: Insulin dependent diabetes mellitus. IGT: Impaired glucose tolerance. IFT: Impaired fasting glucose. LVEF: Left ventricle ejection function. MetS: Metabolic syndrome. NIDDM: non-insulin dependent diabetes mellitus. RBC: Red blood cells. SAVR: Surgical aortic valve replacement. Refers to at least 2 units of RBC transfused § Include paroxysmal, persistent and permanent AF. Data are reported as number or frequency or mean and standard deviation (SD) or median and interquartile range (IQR). AF: Atrial fibrillation. BMI: Body mass index. COPD: Chronic obstructive pulmonary disease. CPB: Cardiopulmonary bypass. ICU: Intensive care unit. IDDM: Insulin dependent diabetes mellitus. IGT: Impaired glucose tolerance. IFT: Impaired fasting glucose. LVEF: Left ventricle ejection function. MetS: Metabolic syndrome. NIDDM: non-insulin dependent diabetes mellitus. RBC: Red blood cells. SAVR: Surgical aortic valve replacement. Refers to at least 2 units of RBC transfused § Include paroxysmal, persistent and permanent AF. Data are reported as number or frequency or mean and standard deviation (SD) or median and interquartile range (IQR). AF: Atrial fibrillation. BMI: Body mass index. COPD: Chronic obstructive pulmonary disease. CPB: Cardiopulmonary bypass. ICU: Intensive care unit. IDDM: Insulin dependent diabetes mellitus. IGT: Impaired glucose tolerance. IFT: Impaired fasting glucose. LVEF: Left ventricle ejection function. MetS: Metabolic syndrome. NIDDM: non-insulin dependent diabetes mellitus. RBC: Red blood cells. SAVR: Surgical aortic valve replacement. Refers to at least 2 units of RBC transfused § Include paroxysmal, persistent and permanent AF. Data are reported as number or frequency or mean and standard deviation (SD) or median and interquartile range (IQR). AF: Atrial fibrillation. BMI: Body mass index. COPD: Chronic obstructive pulmonary disease. CPB: Cardiopulmonary bypass. ICU: Intensive care unit. IDDM: Insulin dependent diabetes mellitus. IGT: Impaired glucose tolerance. IFT: Impaired fasting glucose. LVEF: Left ventricle ejection function. MetS: Metabolic syndrome. NIDDM: non-insulin dependent diabetes mellitus. RBC: Red blood cells. SAVR: Surgical aortic valve replacement. Refers to at least 2 units of RBC transfused § Include paroxysmal, persistent and permanent AF.