Parameter Parameter Responder Non-Responder Non-Responder p-value p-value p-value
Average Symptom Duration Average Symptom Duration 5.1 9.0 9.0 0.06 0.06 0.06
Average Age of Subjects Average Age of Subjects 51.6 53.0 53.0 0.69 0.69 0.69
Average UAS7(Visit 2) ±SE Average UAS7(Visit 2) ±SE 26±3 37±5 37±5 0.12 0.12 0.12
Average UAS7(Visit 5) ±SE Average UAS7(Visit 5) ±SE 7±3 38±4 38±4 0.0003 0.0003 0.0003
Average ΔUAS7(Visit 5 – Visit 2) Average ΔUAS7(Visit 5 – Visit 2) -84% +7.5% +7.5% 0.0009 0.0009 0.0009
Parameter Comparison Group-Visit Comparison Group-Visit Comparison Group-Visit Absolute Value ±SE Absolute Value ±SE Mean difference ±SE Adj. P
UAS7* (Responder-Visit 1) vs. (Non-Responder-Visit 1) (Responder-Visit 1) vs. (Non-Responder-Visit 1) (Responder-Visit 1) vs. (Non-Responder-Visit 1) 26±3 vs. 37±5 26±3 vs. 37±5 -11±7 0.7
(Responder-Visit 5) vs. (Non-Responder-Visit 5) (Responder-Visit 5) vs. (Non-Responder-Visit 5) (Responder-Visit 5) vs. (Non-Responder-Visit 5) 7±3 vs. 38±4 7±3 vs. 38±4 -31±7 0.003
Blood Neutrophil % (Responder-Visit 1) vs. (Non-Responder-Visit 1) (Responder-Visit 1) vs. (Non-Responder-Visit 1) (Responder-Visit 1) vs. (Non-Responder-Visit 1) 57±3 vs. 49±6 57±3 vs. 49±6 8±7 0.7
(Responder-Visit 5) vs. (Non-Responder-Visit 5) (Responder-Visit 5) vs. (Non-Responder-Visit 5) (Responder-Visit 5) vs. (Non-Responder-Visit 5) 59±3 vs. 62±5 59±3 vs. 62±5 -3.0±5 0.9
Blood Eosinophil % (Responder-Visit 1) vs. (Non-Responder-Visit 1) (Responder-Visit 1) vs. (Non-Responder-Visit 1) (Responder-Visit 1) vs. (Non-Responder-Visit 1) 2±0 vs. 8±1 2±0 vs. 8±1 -6±1 0.001
(Responder-Visit 5) vs. (Non-Responder-Visit 5) (Responder-Visit 5) vs. (Non-Responder-Visit 5) (Responder-Visit 5) vs. (Non-Responder-Visit 5) 0±0 vs. 0±1 0±0 vs. 0±1 0±1 1.00
(Non-Responder-Visit 1) vs. (Non-Responder-Visit 5) (Non-Responder-Visit 1) vs. (Non-Responder-Visit 5) (Non-Responder-Visit 1) vs. (Non-Responder-Visit 5) 8±1 vs. 0±1 8±1 vs. 0±1 8±1 0.006
(Responder-Visit 1) vs. (Responder-Visit 5) (Responder-Visit 1) vs. (Responder-Visit 5) (Responder-Visit 1) vs. (Responder-Visit 5) 2±0 vs. 0±0 2±0 vs. 0±0 2±0 0.02
Blood Lymphocyte % (Responder-Visit 1) vs. (Non-Responder-Visit 1) (Responder-Visit 1) vs. (Non-Responder-Visit 1) (Responder-Visit 1) vs. (Non-Responder-Visit 1) 31±3 vs. 34±6 31±3 vs. 34±6 -3±7 0.98
(Responder-Visit 5) vs. (Non-Responder-Visit 5) (Responder-Visit 5) vs. (Non-Responder-Visit 5) (Responder-Visit 5) vs. (Non-Responder-Visit 5) 33±3 vs. 29±5 33±3 vs. 29±5 3±6 0.95
(Non-Responder-Visit 1) vs. (Non-Responder-Visit 5) (Non-Responder-Visit 1) vs. (Non-Responder-Visit 5) (Non-Responder-Visit 1) vs. (Non-Responder-Visit 5) 34±6 vs. 29±5 34±6 vs. 29±5 5±6 0.88
(Responder-Visit 1) vs. (Responder-Visit 5) (Responder-Visit 1) vs. (Responder-Visit 5) (Responder-Visit 1) vs. (Responder-Visit 5) 31±3 vs. 33±3 31±3 vs. 33±3 -2±3 0.94
Blood Basophil % (Responder-Visit 1) vs. (Non-Responder-Visit 1) (Responder-Visit 1) vs. (Non-Responder-Visit 1) (Responder-Visit 1) vs. (Non-Responder-Visit 1) 0.3±0.1 vs. 1.5±0.2 0.3±0.1 vs. 1.5±0.2 -1.2±0.2 0.02
(Responder-Visit 5) vs. (Non-Responder-Visit 5) (Responder-Visit 5) vs. (Non-Responder-Visit 5) (Responder-Visit 5) vs. (Non-Responder-Visit 5) 0.4±0.1 vs. 0.2±0.1 0.4±0.1 vs. 0.2±0.1 0.2±0.2 0.88
(Non-Responder-Visit 1) vs. (Non-Responder-Visit 5) (Non-Responder-Visit 1) vs. (Non-Responder-Visit 5) (Non-Responder-Visit 1) vs. (Non-Responder-Visit 5) 1.5±0.2 vs. 0.2±0.1 1.5±0.2 vs. 0.2±0.1 1.3±0.2 0.05
(Responder-Visit 1) vs. (Responder-Visit 5) (Responder-Visit 1) vs. (Responder-Visit 5) (Responder-Visit 1) vs. (Responder-Visit 5) 0.3±0.1 vs. 0.4±0.1 0.3±0.1 vs. 0.4±0.1 -0.1±0.1 0.93