Regulation of Cutaneous Inflammatory Cell Infiltrates by
Benralizumab
At baseline, the number of mononuclear cells (predominantly lymphocytes)
around perivascular capillaries in the lesional skin were significantly
higher than in the adjacent non-lesional skin (mean difference=18±5
cells/field, p=0.006) (Figure 3 B, D, F ). Such differences were
observed qualitatively when compared with samples from non-CSU control
subjects (Figure 3 A ). Five of 9 subjects completing the study
(56%) who responded completely to benralizumab had reduced mononuclear
cell infiltrates. Comparison of mononuclear cell infiltrates from the
two partial and two non-responder CSU subjects post-benralizumab vs.
post-placebo, also was suggestive of benralizumab’s effect
(Figure 3 B, E, F) with the mean reduction being approximately
17 cells/field (p=0.07). Skin infiltrates from non-lesional skin
post-benralizumab were qualitatively similar to non-CSU (control) skin
samples (Figure 3 A & C ). At baseline, the average mast cell
count in lesional skin was higher compared to adjacent non-lesional
skin, (average difference = 9 cells/field, p=0.2). These differences
persisted after treatment with benralizumab (S-Figure 2 ).