Figure 1: Colocalization plots depicting the association of single nucleotide polymorphisms (SNPs) with cortical ACE gene expression, systolic blood pressure and Alzheimer’s disease (AD) risk. The X axis shows position within the genome (build Hg19) and Y axis denotes the -log10(p-value) for the association. Colour denotes the linkage disequilibrium (LD) between different variants (see legend). The results support that rs4291 is the most likely candidate SNP underlying all these traits, therefore, representing a common causal SNP for these traits.