Data sources
For both colocalization and Mendelian randomization (MR) analyses, data
were obtained from publicly available summary statistics of genome-wide
association studies (GWAS) outlined in Table 1. We selected Parkinson’s
disease, cognitive performance, lacunar stroke and MRI quantified white
matter hyperintensity as outcomes to represent common neurodegenerative
conditions. Lacunar stroke and MRI-quantified white matter
hyperintensity, both which are well-recognised features of vascular
dementia, were used as surrogate outcomes in the absence of available
GWAS for vascular dementia.