Cortex ACE gene expression |
MetaBrain cortical eQTL
GWAS 2021 10
|
6,518 individuals of European ancestry |
Human brain cortex RNA-seq datasets were obtained from 13 different
studies. |
Technical covariates. |
Systolic blood pressure |
Evangelou et al
201811
|
757,601 individuals of European ancestry |
Systolic blood pressure defined as the mean of two automated values.
Correction was made for anti-hypertensive medication use by adding 15
mm Hg to the systolic blood pressure of participants receiving
medication |
Body mass index, sex, age and age2;
study-specific covariates to adjust for technical variation and
population stratification. |
Alzheimer’s disease |
De Rojas et al 202013
|
GWAS meta-analysis of up to (i) 36,675 cases and 58,482 controls, and
Alzheimer’s disease-by-proxy analysis of (ii) 27,696 cases of maternal
Alzheimer’s disease with 260,980 controls, and (iii) 14,338 cases of
paternal Alzheimer’s disease with 245,941 controls, all of European
ancestry. |
Case defined using clinical criteria (Diagnostic and
Statistical Manual of Mental Disorders IVand the National Institute on
Aging and Alzheimer’s Association). Proxy cases defined on the presence
of parental diagnosis of dementia. |
Studies in part (i) were adjusted
for first four genetic principal components (PCs). Studies in part (ii)
and (iii) were adjusted for genetic PCs, age and sex. |
Parkinson’s disease |
Nalls et al 201914
|
GWAS meta-analysis of 37,688 cases and 18,618 UK Biobank proxy-cases
(first-degree relative with Parkinson’s disease) and 1.4 million
controls. |
Cases defined based on clinic visit and UK Brain Bank
criteria for Parkinson’s disease. Proxy cases within UK Biobank defined
by self-reported family history of Parkinson’s disease |
Age at onset in
cases (age at most recent examination for controls), biological sex and
up to the first five genetic PCs |
Lacunar stroke |
Traylor et al 202115
|
GWAS
of 6,030 Cases, 219,389 controls in individuals of European ancestry |
Cases defined using Trial of Org 10172 in Acute Stroke Treatment (TOAST)
criteria for small vessel disease and/or MRI evidence of lacunar stroke |
Genetic PCs. |
White matter hyperintensity |
Persyn et al
202016
|
GWAS of 17,663 individuals of European
ancestry in the UK Biobank |
White matter hyperintensities quantified
using fractional anisotropy on MRI brain. |
Age, sex, assessment centre,
MRI head motion indicators and genetic PCs. |
Cognitive function |
Lee et al 201817
|
Meta-analysis of UK Biobank (n = 222,543) and the COGENT consortium (n =
35,298). All participants of European ancestry. |
Cognition was defined
in the UK Biobank as mean standardised score on a test of
verbal-numerical reasoning. For the COGENT consortium, phenotype defined
as the first principal component derived from three or more
neuropsychological tests. |
Age, sex, interaction for sex and age, first
ten genetic PCs. |