Network analysis
We used the qgraph package in R (v3.6.1) to perform network analysis. A
network is a set of nodes and a set of edges, where each node represents
either an immune parameter or an operational taxonomic unit (OTU) from
microbiome analysis whereas the edges represent associations amongst
them. Pearson correlation coefficients were used to quantify the
strength of associations between combinations of immune parameters or
OTUs.