IMPACT STATEMENT
Improving the understanding of the pathophysiology of allergy and relationship with otitis media is important to develop preventive measures as well as perform adequate monitoring and treatment of children with allergy and otitismedia with effusion,although futures studies are required to increase evidence supporting that anti-allergy treatment may improve resolution and outcome of OME. The evidence linking atopy or allergy to other phenotypes is poor and contradictory and further studies are needed, paying particular attention to accurate phenotyping of otitis media.
TABLE1. Laboratory evidence and biomarkers linking allergy to OME.