References
[1] WHO. Available online at:https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/naming-the-coronavirus-disease-(covid-2019)-and-the-virus-that-causes-it
[2] WHO. Available online at:https://www.who.int/docs/default-source/coronaviruse/situation-reports/wou-4-september-2020-approved.pdf?sfvrsn=91215c78_4
[3] Ministry of Health, Labour and Welfare. Available online at:https://www.mhlw.go.jp/content/10906000/000625626.pdf
[4] Kurihara S, Shibakusa T, Tanaka AK K. Cystine and theanine:
amino acids as oral immunomodulative nutrients. Springer
Plus .2013;2:635.doi:10.1186/2193-1801-2-635
[5] Kurihara S, Shibahara S, Arisaka H, et al. Enhancement of
antigen-specific immunoglobulin G production in mice by
co-administration of L-cystine andL-theanine. J Vet Med Sci 2007;69(12): 1263-1270.
[6] Takagi Y, Kurihara S, Higashi N, et al. Combined administration
of L-cystine and L-theanine enhances
immune functions and protects against influenza virus infection in aged
mice. J Vet Med Sci 2010;72(2):157-165.
[7] Miyagawa K, Hayashi Y, Kurihara S , et al.Co-administration of L-cystine andL-theanine enhances efficacy of influenza vaccination in
elderly persons: nutritional status-dependent immunogenicity.Geriatr Gerontol Int 2008;8:243-250.
[8] Ministry of Health, Labour and Welfare. Available online at:https://www.mhlw.go.jp/content/000618523.pdf
[9] Fujita Health University Okazaki Medical Center. Available
online at:http://www.kansensho.or.jp/uploads/files/topics/2019ncov/covid19_casereport_200313.pdf
[10] Long QX, Tang XJ, Shi QL, et al. Clinical and immunological
assessment of asymptomatic SARS-CoV-2 infection. Nat Med2020;https://doi.org/10.1038/s41591-020-0965-6.
[11] Kurihara S, Yoshida S, Sukegawa E, et al. Evaluation of safety
of long-term and excessive intake of L-cystine and L-theanine in healthy
adult subjects. Seikatsu Eisei 2008;52(4): 229-236.
[12] Murakami S, Kurihara S, Koikawa N, et al. Effects of oral
supplementation with cystine and theanine on the immune function of
athletes in endurance exercise: Randomized, double-blind,
placebo-controlled trial. Biosci Biotechnol Biochem 2009; 73(4):
817-821.
[13] Kawada S, Kobayashi K, Ohtani M , et al. Cystine and theanine
supplementation restores high-intensity resistance exercise-induced
attenuation of natural killer cell activity in well -trained men.J Strength Cond Res 2010;24(3): 846-851.
[14] Murakami S, Kurihara S, Titchenal CA, et al. Suppression of
exercise-induced neutrophilia and lymphopenia in athletes by
cystine/theanine intake: a randomized, double-blind, placebo-controlled
trial. J Int Soc Sport Nutr 2010;23(7):https://doi.org/10.1186/1550-2783-7-23.
[15] Miyachi T, Tsuchiya T, Oyama A, et al. Perioperative oral
administration of cystine and theanine enhances recovery after distal
gastrectomy: a prospective randomized trial. JPEN 2013;37:
384-391.
[16] Shibakusa T, Mikami T, Kurihara S, et al. Enhancement of
postoperative recovery by preoperative oral co-administration of the
amino acids, cystine and theanine, in a mouse surgical model. Clin
Nutr 2012;31: 555-561.
[17] Miyakuni T, Fukatsu K, Ri M, et al. Cystine and theanine
improve survival after gut ischemia-reperfusion. Ann Nutr Metab2018; 73:131-137.doi:10.1159/000489825
[18] Tanaka AK K, Kurihara S, Shibakusa T, et al. Cystine improves
survival rates in a LPS-induced sepsis mouse model. Clin Nutr2015;34: 1159-1165
[19] Matsuu-Matsuyama M, Shichijo K, Tsuchiya T, et al. Protective
effects of a cystine and theanine mixture against acute radiation injury
in rats. Environ Toxicol Pharmacol 2020 PMID: 32325407
doi: 10.1016/j.etap.2020.103395.
[20] Ragab D, Aldin HS, Taeimah M, et al. The COVID-19 cytokine
storm; What we know so far. Front. Immunol. , 16 June 2020
| https://doi.org/10.3389/fimmu.2020.01446
[21] Assimakopoulos FS, Marangos M. N-acetyl-cysteine may prevent
COVID-19-associated cytokine storm and acute respiratory distress
syndrome. Medical Hypotheses 140 (2020) 109778
[22] Flora SD, Balansky R, Maestra SL. Rationale for the use of
N-acetylcysteine in both prevention and adjuvant therapy of COVID-19.
FASEB J 2020; 00:1-9 DOI: 10.1096/fj.202001807
[23] Kurihara S, Hiraoka T, Akutsu M, et al. Effects ofL-cystine and L-theanine supplementation
on the common cold: a randomized, double-blind, and placebo-controlled
trial. J Amino Acids 2010; 307475.
doi:10.4061/2010/307475.