Statistical analyses
Data for continuous parameters were given as mean ± SD or median and interquartile range, depending on the distribution of the data. Categorical variables were presented as percentages. For continuous variables, patterns of distribution were analyzed with visual inspection of histograms and with Shapiro-Wilk test. Comparisons between groups were done with T test for independent samples or with Mann-Whitney U test as appropriate. For categorical variables, either χ2 test or Fisher’s exact test were used to compare groups. Correlation analyses were done with Pearson test or with Spearman’s rho. Finally, a receiver-operator curve was drawn to analyze the accuracy of various biomarkers to predict CMD, with the latter defined as a CFVR <2.0. For all analyses, p value less than 0.05 were accepted as statistically significant. All statistical analyses were done with SPSS 25.0 (IBM Inc, USA).