Associations with acquisition of tolerance
Over the study duration, there were records from 88/169 children who underwent formal oral food challenge for their FPIES triggers. 67 of these children did not react at time of food challenge. The median age for acquisition of tolerance was 25 months (IQR=20-35). Infants who had their first FPIES reaction at a later age were more likely to acquire tolerance at a later age (HR=0.95 per month, CI=0.91-0.99,P= 0.02) (Figure 3). Children with FPIES to rice and other grains were likely to acquire tolerance at an earlier age (HR=1.9, CI=1.2-3.2,P =.0099) whilst children with FPIES to fish were likely to acquire tolerance at a later age (HR 0.2, CI=0.08-0.6, P =.0039) (Figure 4). No other factors affected age of tolerance acquisition (Figure 3).