Effects of estrogen on sodium currents and Nav1.5 expression are inconsistent
Sodium currents are mainly generated by Nav1.5 (Jiang et al., 2020). Here, we examined the relationship between effects of estrogen on sodium currents and Nav1.5. Notably, low and medium concentrations of estrogen decreased the content of Nav1.5, while high concentrations upregulated the content of Nav1.5. This partly indicates that the effects of estrogen were concentration-dependent as reported previously (Kurokawa et al., 2016; Kurokawa et al., 2008). Under stress state, estrogen at all concentrations reversed the increase in content of Nav1.5 caused by ISO. However, the changes in the content of Nav1.5 did not match with the changes inI NaL and I Na.