Novelty and therapeutic implications
This work provides novel insights into the cardioprotective effect of
estrogen in the condition of excessive stimulation of β-adrenergic
receptors. Our data reveals that GPER activation mediates estrogenic
effects on cardiomyocytes to attenuate sodium current and maintain
normal action potential duration under stress state. Thus, GPER may be a
novel target to treat stress-related heart diseases.