Silencing GPER suppressed the effect of estrogen on
INaL and altered INa kinetics under
stress
In hiPSC-CMs treated with ISO, silencing GPER canceled the inhibitory
effects of E2 on I NaL (Figure 7F and H). Despite
E2 having no influence on the V1/2 values of
inactivation, GPER silencing decreased it under stress challenge
(Supplemental Figure 5H and J-M). GPER silencing did not affect the τ
value of recovery from inactivation caused by ISO (Supplemental Figure
4B, Supplemental Figure 5I and N). Detailed statistical data are
available in supplementary material online, Supplemental Table
1-7.