Silencing GPER suppressed the effect of estrogen on INaL and altered INa kinetics under stress
In hiPSC-CMs treated with ISO, silencing GPER canceled the inhibitory effects of E2 on I NaL (Figure 7F and H). Despite E2 having no influence on the V1/2 values of inactivation, GPER silencing decreased it under stress challenge (Supplemental Figure 5H and J-M). GPER silencing did not affect the τ value of recovery from inactivation caused by ISO (Supplemental Figure 4B, Supplemental Figure 5I and N). Detailed statistical data are available in supplementary material online, Supplemental Table 1-7.