Statistical analysis
Statistical analysis was performed using IBM SPSS 21 statistical software. Continuous and categorical variables are reported as mean±standard deviation (SD) or as percentages, respectively. Continuous variables were compared between two groups using the t-test and the ANOVA model for repeated measures was performed and validated using Mauchly’s test of sphericity with Greenhouse-Geisser correction. A stepwise logistic regression multivariable analysis was performed, to assess the simultaneous effect of several variables on the primary outcome (PPI). The variables included in the analysis were LVEF, age, sex, CRP, mean aortic PG, FACTS score, implantation depth (mean and non-coronary cusp), valves types, bicuspid aortic valve, non-coronary cusp calcification, NLR at any moment. A ROC curve analysis was applied to find a cut point, if necessary. A p value (two sided) of less than 0.05 was considered significant.