Conclusion:
With the latest pandemic due to COVID-19 infection a lot of patients were vulnerable and at risk of developing severe and fatal complications. Patients with SCD suffer from multiple acute and chronic complications. The exact clinical course of COVID-19 infection in those patients is not yet final and conflicting data are available. However, delaying appropriate management may carry an increased risk for intubation and mortality. We recommend that physicians should keep a low threshold for admitting SCD patients in whom they suspect COVID-19 infection and to monitor them closely as well provide RBCs exchange initially in the disease course to give them the benefit of doubt. More research is needed to reach a high evidence regarding the management plan.