Placebo (N=458) Placebo (N=458) 12 SQ-Bet (N=471) 12 SQ-Bet (N=471) Overall (N=929) Overall (N=929)
N %n N %n N %n
Sex Sex Sex Sex Sex Sex Sex
Male 220 (48%) 227 (48%) 447 (48%)
Female 238 (52%) 244 (52%) 482 (52%)
Age Age Age Age Age Age Age
Mean (SD) 36.1 (13.2) 36.1 (13.2) 37.3 (13.4) 37.3 (13.4) 36.7 (13.3) 36.7 (13.3)
Min – Max 12.0 - 65.0 12.0 - 65.0 12.0 - 65.0 12.0 - 65.0 12.0 - 65.0 12.0 - 65.0
SPT SPT SPT SPT SPT SPT SPT
Birch only 8 (2%) 11 (2%) 19 (2%)
Birch homologous group only 88 (19%) 99 (21%) 187 (20%)
Birch homologous group only + others 369 (81%) 372 (79%) 741 (80%)
Bet v 1 specific IgE class Bet v 1 specific IgE class Bet v 1 specific IgE class Bet v 1 specific IgE class Bet v 1 specific IgE class Bet v 1 specific IgE class Bet v 1 specific IgE class
2-3 226 (49%) 226 (48%) 452 (49%)
4-6 232 (51%) 243 (52%) 475 (51%)
Unknown - - 2 (<1%) 2 (<1%)
Birch allergy Birch allergy Birch allergy Birch allergy Birch allergy Birch allergy Birch allergy
Birch AR/C 458 (100%) 471 (100%) 929 (100%)
Years with AR/C, mean (SD) 17.0 (11.8) 17.0 (11.8) 15.8 (10.8) 15.8 (10.8) 16.4 (11.3) 16.4 (11.3)
Asthma (any cause) Asthma (any cause) Asthma (any cause) Asthma (any cause) Asthma (any cause) Asthma (any cause) Asthma (any cause)
Asthma at baseline 168 (37%) 184 (39%) 352 (38%)
Years with asthma, mean (SD) 12.9 (10.7) 12.9 (10.7) 12.0 (10.7) 12.0 (10.7) 12.4 (10.7) 12.4 (10.7)
PFS PFS PFS PFS PFS PFS PFS
PFS at baseline 296 (65%) 296 (63%) 592 (64%)
Years with PFS, mean (SD) 14.9 (11.3) 14.9 (11.3) 14.2 (10.9) 14.2 (10.9) 14.5 (11.1) 14.5 (11.1)