DIZE upregulated RV and pulmonary Ang-(1-7) levels
The RV and pulmonary tissue Ang-(1-7) levels were not changed in the
SuPNx42 group when compared to the sham-operated rats
(Figures 6A and 6B). However, there was a significant increase of RV
Ang-(1-7) in both the early and late DIZE treatment groups when compared
with the vehicle-treated SuPNx42 rats (Figures 6A and
6B). In addition, early DIZE treatment also increased the levels of
pulmonary Ang-(1-7) when compared with the SuPNx42 group
(Figure 6B). No significant differences were found among the
sham42, SuPNx42, and
SuPNx42/DIZE29–42 groups (Figure 6B).