Data analysis
The data and statistical analysis comply with the recommendations of the
British Journal of Pharmacology on experimental design and analysis in
pharmacology (Curtis et al., 2018). Sample
sizes subjected to statistical analysis at least n = 10, where n =
number of independent values. Data are expressed as the mean ± SD, and
statistical significance was determined by analysis of variance and
Student’s t -tests. P -values < 0.05 were
considered statistically significant.