Animals
Female Balb/c mice (6 weeks old , 18.1±1.4g) were housed in specific
pathogen-free (SPF) conditions at 21 to 24 °C and 40% to 60% relative
humidity with a 12 h light-dark cycle. All the animals were acclimatized
for at least one week prior to the start of the experiments. All studies
were performed in accordance with the guidelines for animal
experimentation by Wonkwang University and were approved by the
university’s Institutional Animal Care and Use Committee (Approval No.
WKU13-50, WKU18-43).