Exclusion criteria
Publications were excluded if they were: (1) molecular and animal
studies, literature reviews, conference paper, observational studies,
case reports, republished data, book, letters, (2) Non interventional,
un-controlled and nonrandomized trials, (3) without adequate outcome for
both baseline and the end of trial. (4) In addition, unpublished data
and gray literature such as patents, congress abstracts, and
dissertations were excluded.