Exclusion criteria
Publications were excluded if they were: (1) molecular and animal studies, literature reviews, conference paper, observational studies, case reports, republished data, book, letters, (2) Non interventional, un-controlled and nonrandomized trials, (3) without adequate outcome for both baseline and the end of trial. (4) In addition, unpublished data and gray literature such as patents, congress abstracts, and dissertations were excluded.