Inclusion criteria
Potentially relevant studies were included if they met the following inclusion criteria: (1) original papers with either parallel or cross-over randomized clinical trials (RCT) design; (2) studies conducting on individuals aged 18 years old or more; (3) investigating the impact of orlistat on uric acid (4) providing required information on outcomes at both baseline and the end of trial (or reported changes in outcomes) for each group (orlistat/control),(5) publications examining the effects of orlistat in combination with other interventions and (6) full-text publication was written in English;.. After removal of duplicates, two reviewers independently screened studies by title, abstract, and full text as applicable for inclusion.