Inclusion criteria
Potentially relevant studies were included if they met the following
inclusion criteria: (1) original papers with either parallel or
cross-over randomized clinical trials (RCT) design; (2) studies
conducting on individuals aged 18 years old or more; (3) investigating
the impact of orlistat on uric acid (4) providing required information
on outcomes at both baseline and the end of trial (or reported changes
in outcomes) for each group (orlistat/control),(5) publications
examining the effects of orlistat in combination with other
interventions and (6) full-text publication was written in English;..
After removal of duplicates, two reviewers independently screened
studies by title, abstract, and full text as applicable for inclusion.