Data analysis:
Descriptive statistics of variables were expressed as medians and interquartile range (IQR), according to the analysis of the distribution of data, while qualitative variables were summarized using frequency and percentages. Second, ALT and AST values were analyzed in three periods: before, during, and after the suspension of PP to establish differences in these periods. For the overall analysis of the three periods the Kruskal Wallis and Mann Whitney U tests were used to determine differences between 2 periods (before vs. during, during vs. after, and before vs. after). The Stata® v16 statistical software (Stata Corporation, College Station, Texas, USA) was used for the analyses. A value of p < 0.05 was considered statistically significant.
Ethical aspects :
The study protocol was approved by the Institutional Review Board of the INSN-SB, under the institutional code PI-210-2018.