Effects of creatine supplementation on LDH concentration
As outlined in Figure 3 and Table 3 , our preliminary analysis indicated that creatine supplementation have no significant effect in serum LDH concentration compared to placebo (WMD = -5.99; 95% CI: -14.49, 2.50; P= 0.167). Also, significant heterogeneity was observed among studies (P= 0.014, I2 = 47.2 %). Some of subgroup analysis showed that creatine consumption resulted in a significant reduction in LDH concentrations in trials with 48 hours measurement of LDH after exercise and >20 g/day creatine consumption.