SUMMARY:
- What is already known: Renovascular hypertension is an underlying
cause of secondary and resistant hypertension.
- What this study adds: Angiotensin II stimulation of renal vasculature
elevates sGC expression via an AT1R and FoxO-dependent
mechanism.
- Clinical significance: Enhanced sGC-mediated cGMP signaling affords
protection through decreased renovascular tone and increased renal
blood flow.