ACKNOWLEDGEMENTS:
We would like to acknowledge the Center for Biological Imaging at the University of Pittsburgh for its support and confocal microscope usage and Dr. Delphine Gomez for use of her microscope at the University of Pittsburgh. Financial support for this work was provided by the National Institutes of Health (NIH) [grants R01 HL 133864 and R01 HL 128304], American Heart Association (AHA) Grant-in-Aid [16GRNT27250146] (A.C.S.), NIH F31 Pre-Doctoral Fellowship Award [HL 151173], Louis J. Ignarro Cardiovascular Fellowship [5T32GM008424], NIH T32 Division of Geriatrics Aging Institute Fellowship [AG021885] (J.C.G.), NIH T32 Post-Doctoral Fellowship Award [DK007052] (B.G.D.), NIH [grants DK091190, HL109002, HL069846, DK079307 (E.K.J.), and NIH [grant R01 HL152680 (S.D.S.)]. We would also like to acknowledge the support of Dr. Katherine C. Wood for her help editing and reviewing the manuscript for publication.