Association between antibiotic exposure within 6 months of age
and IL-13 gene polymorphism on the phenotypes of AD
In the final model, we considered the combined effects of IL-13gene polymorphism and antibiotic exposure within the first 6 months of
age on the phenotypes of AD. TheIL-13 (rs20541) GA+AA genotype was associated with
early-persistent AD when the non-AD with GG genotype was considered as a
reference (Table 5). Of children with the IL-13 (rs20541) GA+AA
genotype, children who were exposed with antibiotics more than 2 times
was associated with a higher risk of early-persistent AD than those who
were exposed with antibiotics only once, and this effect was even
pronounced in infants who were never exposed with antibiotics (never:
aOR=2.06, 95% CI 1.13-3.77; once: aOR=2.99, 95% CI 1.44–6.22; ≥2
times: aOR=4.73, 95% CI 2.01–11.14).