Treatment Protocol
The treatment protocol was designed as an intralesional injection of 40
mg methylprednisolone to the maximum curvature point; this injection was
repeated once a week for 8 weeks. No local anesthesia was performed
before injection, but patients were allowed to use non-steroidal
anti-inflammatory drugs and pain killers after injection. A 23G needle
was used for injection. The dosage was 40 mg of the drug in its pure
form (no dilution), which was loaded into a syringe and then inserted
into the plaque at a right angle. The drug was then injected at
different points of the plaque by slightly moving the needle around the
injection point.
During the protocol, treatment was terminated and the patient was
excluded from the study in cases of an unexpected side effects or
worsening disease symptoms. All adverse events were recorded during the
study period. All procedures were performed by a single experienced
urologist.
All patients voluntarily signed their consent to participate in the
study. The study was approved by the Ethics Committee of Eskişehir
Osmangazi University Faculty of Medicine.