Study Limitations
The main limitation of the current study was the low number of patients.
Additionally, it is not a placebo-controlled randomized study. However,
we believe that the results obtained from our study are likely to be
replicated in comprehensive double-blind randomized placebo-controlled
studies that should be done in the future. One of the methodological
limitations was the preferred method of plaque size measuring. Using
ultrasound for measuring the plaque size is easy but not reliable
because the variable and subjective measurement depends on the person
who performs the ultrasound. In order to minimize this subjectivity, all
ultrasound procedures were performed by same clinician. Finally, the
short follow up time after treatment protocol negatively affected the
expected change in IIEF scores because IIEF is made to evaluate erectile
function in the past six months.