Study Limitations
The main limitation of the current study was the low number of patients. Additionally, it is not a placebo-controlled randomized study. However, we believe that the results obtained from our study are likely to be replicated in comprehensive double-blind randomized placebo-controlled studies that should be done in the future. One of the methodological limitations was the preferred method of plaque size measuring. Using ultrasound for measuring the plaque size is easy but not reliable because the variable and subjective measurement depends on the person who performs the ultrasound. In order to minimize this subjectivity, all ultrasound procedures were performed by same clinician. Finally, the short follow up time after treatment protocol negatively affected the expected change in IIEF scores because IIEF is made to evaluate erectile function in the past six months.