Conclusion
Cryptococcus neoformans fungemia is not that common in HIV-infected patients, and co-infections with more than three opportunistic infections are extremely rare specially, Cryptococcus neoformans, Mycobacterium and Pneumocystis jiroveci pneumonia (PCP). for that reason, in late HIV detected cases and in advanced stages of immunosuppression, a high level of suspicion of systemic mycoses and concurrent infection by several opportunistic pathogens is required in severely immunocompromised patients.