Conclusion
Despite more than two decades of improved overall health care outcomes for patients with SCD, the transition from pediatric to adult health care continues to be associated with adverse health outcomes. Advancements in the medical management of SCD have resulted in a growing population of young adults living with SCD. Our analysis noted that all young adult patients had increased hospitalizations with age, however, only in the sickle cell cohort was there an increase in mortality with increasing age. Specifically, we have shown that mortality between young adults is 2-3x higher than in older teens. This highlights the necessity of maximizing disease-modifying therapies and engaging in transition-readiness programs that target social determinants of health.