2.5. Quality Assessment
To assess the risk of bias among the included studies, we used the
Cochrane’s risk of bias tool.27 This tool evaluates
the following domains: random sequence generation (selection bias),
allocation concealment (selection bias), blinding of participants and
personnel (performance bias), blinding of outcome assessment (detection
bias), incomplete outcome data (attrition bias), selective outcome
reporting (reporting bias) and other potential sources of bias. Two
investigators independently assessed the quality of the eligible studies
and discrepancies were resolved by a third investigator, if applicable.
The investigators’ judgment comprised low, unclear, or high risk of bias
for each evaluated domain.