2.5. Quality Assessment
To assess the risk of bias among the included studies, we used the Cochrane’s risk of bias tool.27 This tool evaluates the following domains: random sequence generation (selection bias), allocation concealment (selection bias), blinding of participants and personnel (performance bias), blinding of outcome assessment (detection bias), incomplete outcome data (attrition bias), selective outcome reporting (reporting bias) and other potential sources of bias. Two investigators independently assessed the quality of the eligible studies and discrepancies were resolved by a third investigator, if applicable. The investigators’ judgment comprised low, unclear, or high risk of bias for each evaluated domain.