Abbreviations
NSCLC: non-small cell lung cancer; OS: overall survival; DTIP: Direct thrombin inhibitor peptide; r-hirudin: recombinant hirudin; PAR-1: Proteinase-activated receptors; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; gRNA: guide RNA; NF-κB: nuclear factor κB; HUVEC: human umbilical vein endothelial cells, VEGF: Vascular endothelial growth factor.