2.3 Subjects
At screening, subjects were deemed healthy based on medical history,
physical examination, ECG, vital signs and laboratory tests. Key
non-inclusion criteria included presence or history of severe allergies,
recent use of any prescription medicine, blood loss
> 400 mL or participation in another clinical study in the
past 3 months.
To preclude any dietary effects on the PK of emodepside, subjects in the
fasting cohorts fasted for 9 hours (10 hours in the RBA study) before
receiving the IP. Subjects in the fed cohorts fasted for 10 hours prior
to dosing and received a standard high-calorie, high-fat breakfast
30 minutes prior to dosing.