2.3 Subjects
At screening, subjects were deemed healthy based on medical history, physical examination, ECG, vital signs and laboratory tests. Key non-inclusion criteria included presence or history of severe allergies, recent use of any prescription medicine, blood loss > 400 mL or participation in another clinical study in the past 3 months.
To preclude any dietary effects on the PK of emodepside, subjects in the fasting cohorts fasted for 9 hours (10 hours in the RBA study) before receiving the IP. Subjects in the fed cohorts fasted for 10 hours prior to dosing and received a standard high-calorie, high-fat breakfast 30 minutes prior to dosing.