Part 1 Part 1 Part 1 Part 1 Part 1 Part 2 Part 2
LSF 5 mg ASD tablet 5 mg ASD tablet 5 mg ASD tablet 5 mg ASD tablet 5 mg ASD tablet 10 mg ASD tablet 10 mg
Fasting N=11 GR fasting N=11 GS fasting N=10 GR fed N=12 GS fed N=11 GR fasting N=12 GS fasting N=10
AUClast (hng/mL) 1160 (43.7) 856 (19.2) 921 (24.0) 677 (32.3) 735 (35.0) 1665 (32.2) 1990 (29.9)
AUC0-7d (hng/mL) 1215 (37.2) 852 (19.1) 931 (23.3) 674 32.1) 733 (34.9) 1609 (35.9) 1943 (26.5)
AUC0-7d/D ([hng/mL]/mg) 243 37.2) 170 (19.1) 186 (23.3) 135 (32.1) 147 34.9) 161 (35.9) 194 (26.5)
Cmax (ng/mL) 88.5 (20.1) 41.9 (20.0) 54.2 (35.3) 27.1 (26.8) 36.2 (39.8) 71.7 (28.5) 135 (35.3)
Cmax/D ([ng/mL]/mg) 17.7 (20.1) 8.38 (20.0) 10.8 (35.3) 5.41 (26.8) 7.24 (39.8) 7.17 (28.5) 13.5 (35.3)
tmax (h) 1.00 (0.50–1.50) 4.00 (2.50–6.00) 1.50 (1.00–2.52) 5.01 (1.50–8.00) 3.00 (2.00–6.00) 3.50 (2.50–6.00) 1.50 (1.00–2.50)
Terminal t½ (h) 220 (87.1) 234 (71.2) 253 (53.0) 235 (75.7) 208 (63.9) 238 (100.6) 233 (90.2)
t ½ 0-24* (h) 11.0 (31.6) 10.0 (20.6) 11.0 (29.1) 10.5 (22.9) 11.1 (31.7) 9.23 (21.6) 10.7 (17.1)
λz (1/h) 0.00315 (87.1) 0.00296 (71.2) 0.00274 (53.0) 0.00295 (75.7) 0.00334 (63.9) 0.00291 (100.6) 0.00297 (90.2)
MRTlast (h) 48.1 (45.1) 55.9 (7.4) 54.2 (15.4) 60.6 (5.4) 58.5 (9.3) 60.2 (21.1) 57.9 (13.8)