|
5 mg OD LSF fasting |
5 mg OD LSF fasting |
10 mg OD LSF fasting |
10 mg OD LSF fasting |
10 mg BID LSF fasting |
10 mg BID LSF
fasting |
|
Day 0 |
Day 9 |
Day 0 |
Day 9 |
Day 0 |
Day 9 |
AUClast
(hng/mL)
|
–
(–)
|
19359
(29.9)
|
–
(–)
|
40655
(43.5)
|
–
(–)
|
59554
(29.1)
|
AUClast/D
([hng/mL]/mg)
|
–
(–)
|
3872
(29.9)
|
–
(–)
|
4065
(43.5)
|
–
(–)
|
5955
(29.1)
|
AUC0-24
(hng/mL)
|
574
(19.7)
|
1689
(31.3)
|
1135
(32.7)
|
3487
(44.2)
|
1428
(26.5)
|
4897
(35.8)
|
AUC0-24/D
([hng/mL]/mg)
|
115
(19.7)
|
338
(31.3)
|
113
(32.7)
|
349
(44.2)
|
71.4
(26.5)
|
490
(35.8)
|
Cmax
(ng/mL)
|
93.8
(17.8)
|
149
(17.9)
|
186
(21.3)
|
287
(39.7)
|
160
(20.4)
|
349
(27.1)
|
Cmax/D
([ng/mL]/mg)
|
18.8
(17.8)
|
29.9
(17.9)
|
18.6
(21.3)
|
28.7
(39.7)
|
16.0
(20.4)
|
34.9
(27.1)
|
Ctrough*
(ng/mL)
|
–
(–)
|
49.7
(36.8)
|
–
(–)
|
97.1
(50.8)
|
–
(–)
|
185
(39.5)
|
tmax
(h)
|
1.00
(1.00-1.07)
|
1.00
(1.00-1.50)
|
1.25
(1.00-2.00)
|
1.25
(1.00-2.00)
|
1.00
(1.00-1.58)
|
1.50
(1.03-2.50)
|
Terminal t½
(h)
|
–
(–)
|
419
(42.6)
|
–
(–)
|
450
(30.6)
|
–
(–)
|
508
(56.9)
|
t ½ 0-24**
(h)
|
–
(–)
|
26.9
(52.4)
|
–
(–)
|
18.4
(30.0)
|
–
(–)
|
33.2
(55.0)
|
λz
(1/h)
|
–
(–)
|
0.00166
(42.6)
|
–
(–)
|
0.00154
(30.6)
|
–
(–)
|
0.00137
(56.9)
|
CLss/F
(L/h)
|
–
(–)
|
2.96
(31.3)
|
–
(–)
|
2.87
(44.2)
|
–
(–)
|
3.56
(35.0)
|
Vz/F
(L)
|
–
(–)
|
1788
(74.2)
|
–
(–)
|
1861
(68.5)
|
–
(–)
|
2607
(102.1)
|
MRTlast
(h)
|
7.28
(10.7)
|
–
(–)
|
7.00
(11.0)
|
–
(–)
|
10.8
(2.8)
|
–
(–)
|