1 mg LSF fasting 2.5 mg LSF fasting 5 mg LSF fasting 10 mg LSF fasting 20 mg LSF fasting 40 mg LSF fasting 5 mg IRT fasting 20 mg IRT fasting 10 mg LSF fed
AUClast (hng/mL) 182 111 845 10.4 1700 24.2 3070 27.7 7480 22.1 16400 23.6 501 76.8 667 125 3390 20.4
AUC0-24 (hng/mL) 100 50.4 250 6.5 522 25.8 996 21.2 1910 16.3 4110 33.6 183 24.3 223 58.0 673 26.4
AUC0-24/D ([hng/mL]/mg) 100 50.4 100 6.50 104 25.8 99.6 21.2 95.3 16.3 103 33.6 36.5 24.3 11.2 58.0 67.3 26.4
Cmax (ng/mL) 18.6 20.8 37.6 15.5 92.1 16.2 172 32.3 306 28.7 595 27.9 25.7 23.9 30.2 62.5 71.9 29.6
Cmax/D ([ng/mL]/mg) 18.6 20.8 15.0 15.5 18.4 16.2 17.2 32.3 15.3 28.7 14.9 27.9 5.15 23.9 1.51 62.5 7.19 29.6
tmax (h) 1.00 (1.00-1.05) 1.00 (1.00-2.50) 1.00 (1.00-1.50) 1.00 (1.00-1.00) 1.50 (1.00-2.53) 1.05 (1.00-8.00) 2.00 (1.02-2.55) 2.00 (1.50-2.02) 2.50 2.00-2.52
Terminal t½ (h) 42.7 531 449 74.0 415 117 365 286 590 68.1 392 31.7 267 392 348 171 531 99.3
t ½ 0-24* (h) 8.45 84.7 10.6 24.9 11.6 21.7 10.9 26.8 10.5 28.7 11. 1 24.7 10.8 9.2 11.3 23.8 11.1 33.9