5 mg OD LSF fasting 5 mg OD LSF fasting 10 mg OD LSF fasting 10 mg OD LSF fasting 10 mg BID LSF fasting 10 mg BID LSF fasting
Day 0 Day 9 Day 0 Day 9 Day 0 Day 9
AUClast (hng/mL) – (–) 19359 (29.9) – (–) 40655 (43.5) – (–) 59554 (29.1)
AUClast/D ([hng/mL]/mg) – (–) 3872 (29.9) – (–) 4065 (43.5) – (–) 5955 (29.1)
AUC0-24 (hng/mL) 574 (19.7) 1689 (31.3) 1135 (32.7) 3487 (44.2) 1428 (26.5) 4897 (35.8)
AUC0-24/D ([hng/mL]/mg) 115 (19.7) 338 (31.3) 113 (32.7) 349 (44.2) 71.4 (26.5) 490 (35.8)
Cmax (ng/mL) 93.8 (17.8) 149 (17.9) 186 (21.3) 287 (39.7) 160 (20.4) 349 (27.1)
Cmax/D ([ng/mL]/mg) 18.8 (17.8) 29.9 (17.9) 18.6 (21.3) 28.7 (39.7) 16.0 (20.4) 34.9 (27.1)
Ctrough* (ng/mL) – (–) 49.7 (36.8) – (–) 97.1 (50.8) – (–) 185 (39.5)
tmax (h) 1.00 (1.00-1.07) 1.00 (1.00-1.50) 1.25 (1.00-2.00) 1.25 (1.00-2.00) 1.00 (1.00-1.58) 1.50 (1.03-2.50)
Terminal t½ (h) – (–) 419 (42.6) – (–) 450 (30.6) – (–) 508 (56.9)
t ½ 0-24** (h) – (–) 26.9 (52.4) – (–) 18.4 (30.0) – (–) 33.2 (55.0)
λz (1/h) – (–) 0.00166 (42.6) – (–) 0.00154 (30.6) – (–) 0.00137 (56.9)
CLss/F (L/h) – (–) 2.96 (31.3) – (–) 2.87 (44.2) – (–) 3.56 (35.0)
Vz/F (L) – (–) 1788 (74.2) – (–) 1861 (68.5) – (–) 2607 (102.1)
MRTlast (h) 7.28 (10.7) – (–) 7.00 (11.0) – (–) 10.8 (2.8) – (–)