Figure Legends
Figure 1. Violin plots showing the probability distribution of lung
volumes according to the quartile distribution of the VHI % in children
with problematic wheeze/asthma. In A), the non-ventilated compartment
was significantly greater in children with VHI % in the upper quartile,
and in B) the hypoventilated compartment likewise was significantly
higher. In C) the ventilated compartment volume was not significantly
different among the VHI % quartiles, however in D) the well-ventilated
compartment was significantly lower in children with VHI % in the upper
quartile compared to children with VHI % in the lower quartile.
Figure 2. Representative HHe-3 images from children with mild, moderate,
and severe ventilation heterogeneity. The VHI % located below each
image was derived from the non-ventilated and hypoventilated volume
divided by the total lung volume. Regional maps of the lung volume
compartments are indicated by a color labeling algorithm. The table
compares phenotypic features that were significantly (p < .05)
different in children with VHI % in the upper quartile compared to
children in the lower quartile.
Figure 3. Within subject analysis of granulocyte counts/hpf in BAL
return from ventilated and non-ventilated lung regions in 13 children
with asthma. Ventilation status of a lung region was determined
according to the presence or absence of visible ventilation defects on
HHe-3 lung MRI. The plots are probability density functions and paired
counts of A) macrophage, B) lymphocyte, C) eosinophil, and D) neutrophil
numbers according to regional ventilation status.