Figure Legends
Figure 1. Violin plots showing the probability distribution of lung volumes according to the quartile distribution of the VHI % in children with problematic wheeze/asthma. In A), the non-ventilated compartment was significantly greater in children with VHI % in the upper quartile, and in B) the hypoventilated compartment likewise was significantly higher. In C) the ventilated compartment volume was not significantly different among the VHI % quartiles, however in D) the well-ventilated compartment was significantly lower in children with VHI % in the upper quartile compared to children with VHI % in the lower quartile.
Figure 2. Representative HHe-3 images from children with mild, moderate, and severe ventilation heterogeneity. The VHI % located below each image was derived from the non-ventilated and hypoventilated volume divided by the total lung volume. Regional maps of the lung volume compartments are indicated by a color labeling algorithm. The table compares phenotypic features that were significantly (p < .05) different in children with VHI % in the upper quartile compared to children in the lower quartile.
Figure 3. Within subject analysis of granulocyte counts/hpf in BAL return from ventilated and non-ventilated lung regions in 13 children with asthma. Ventilation status of a lung region was determined according to the presence or absence of visible ventilation defects on HHe-3 lung MRI. The plots are probability density functions and paired counts of A) macrophage, B) lymphocyte, C) eosinophil, and D) neutrophil numbers according to regional ventilation status.