Table II BAL Constituents Compared According to VHI % Dispersion Table II BAL Constituents Compared According to VHI % Dispersion Table II BAL Constituents Compared According to VHI % Dispersion Table II BAL Constituents Compared According to VHI % Dispersion Table II BAL Constituents Compared According to VHI % Dispersion Table II BAL Constituents Compared According to VHI % Dispersion Table II BAL Constituents Compared According to VHI % Dispersion Table II BAL Constituents Compared According to VHI % Dispersion Table II BAL Constituents Compared According to VHI % Dispersion Table II BAL Constituents Compared According to VHI % Dispersion Table II BAL Constituents Compared According to VHI % Dispersion Table II BAL Constituents Compared According to VHI % Dispersion Table II BAL Constituents Compared According to VHI % Dispersion
Total Cell and Granulocyte Counts Total Cell and Granulocyte Counts Total Cell and Granulocyte Counts Total Cell and Granulocyte Counts Total Cell and Granulocyte Counts Total Cell and Granulocyte Counts Total Cell and Granulocyte Counts Total Cell and Granulocyte Counts Total Cell and Granulocyte Counts Total Cell and Granulocyte Counts Total Cell and Granulocyte Counts Total Cell and Granulocyte Counts Total Cell and Granulocyte Counts
Constituent
Constituent
Constituent
Mild VH 25th %ile Mild VH 25th %ile Mild VH 25th %ile Mod. VH 25th-75th %ile Mod. VH 25th-75th %ile Severe VH 75th %ile Severe VH 75th %ile Severe VH 75th %ile
Total
Total
Sample n Sample n Sample n 4 4 4 12 12 6 6 6 22 22
Total Cell Count (X 106 ) Total Cell Count (X 106 ) Total Cell Count (X 106 ) 1.44 ± 1.44 1.44 ± 1.44 1.44 ± 1.44 1.47 ± 3.62 1.47 ± 3.62 1.14 ± 2.35 1.14 ± 2.35 1.14 ± 2.35 1.17 ± 1.58 1.17 ± 1.58
Eosinophils (%) Eosinophils (%) Eosinophils (%) 0 ± 2 0 ± 2 0 ± 2 0 ± 0 0 ± 0 1 ± 8 1 ± 8 1 ± 8 0 ± 2 0 ± 2
BAL eosinophils ≥ 1% n (%) BAL eosinophils ≥ 1% n (%) BAL eosinophils ≥ 1% n (%) 1 (25) 1 (25) 1 (25) 2 (17) 2 (17) 3 (50) 3 (50) 3 (50) 6 (27) 6 (27)
Neutrophils (%) Neutrophils (%) Neutrophils (%) 5 ± 4 5 ± 4 5 ± 4 4 ± 15 4 ± 15 15 ± 32 15 ± 32 15 ± 32 5 ± 18 5 ± 18
BAL neutrophils ≥ 6 % n (%) BAL neutrophils ≥ 6 % n (%) BAL neutrophils ≥ 6 % n (%) 1 (25) 1 (25) 1 (25) 3 (25) 3 (25) 4 (67) 4 (67) 4 (67) 8 (36) 8 (36)
Lymphocytes (%) Lymphocytes (%) Lymphocytes (%) 3 ± 3 3 ± 3 3 ± 3 3 ± 4 3 ± 4 1 ± 8 1 ± 8 1 ± 8 3 ± 3 3 ± 3
Macrophages (%) Macrophages (%) Macrophages (%) 68 ± 26 68 ± 26 68 ± 26 72 ±32 72 ±32 58 ± 40 58 ± 40 58 ± 40 68 ± 37 68 ± 37
Epithelial cells (%) Epithelial cells (%) Epithelial cells (%) 21 ± 25 21 ± 25 21 ± 25 12 ± 23 12 ± 23 21 ± 23 21 ± 23 21 ± 23 20 ± 25 20 ± 25
Granulocyte Categories * Granulocyte Categories * Granulocyte Categories * Granulocyte Categories * Granulocyte Categories * Granulocyte Categories * Granulocyte Categories * Granulocyte Categories * Granulocyte Categories * Granulocyte Categories * Granulocyte Categories * Granulocyte Categories * Granulocyte Categories *
Isolated Eosinophilia Isolated Eosinophilia Isolated Eosinophilia 0 0 1 (8) 1 (8) 1 (8) 1 (8) 1(17) 1(17) 1(17) 2 (9)
Isolated Neutrophilia Isolated Neutrophilia Isolated Neutrophilia 0 0 2 (17) 2 (17) 2 (17) 2 (17) 2 (33) 2 (33) 2 (33) 4 (18)
Mixed Granulocytic Mixed Granulocytic Mixed Granulocytic 1 (25) 1 (25) 1 (8) 1 (8) 1 (8) 1 (8) 2 (33) 2 (33) 2 (33) 4 (18)
Pauci-granulocytic Pauci-granulocytic Pauci-granulocytic 3 (75) 3 (75) 8 (67) 8 (67) 8 (67) 8 (67) 1 (17) Ϯ 1 (17) Ϯ 1 (17) Ϯ 12 (54)
Potential Lower Respiratory Pathogens α Potential Lower Respiratory Pathogens α Potential Lower Respiratory Pathogens α Potential Lower Respiratory Pathogens α Potential Lower Respiratory Pathogens α Potential Lower Respiratory Pathogens α Potential Lower Respiratory Pathogens α Potential Lower Respiratory Pathogens α Potential Lower Respiratory Pathogens α Potential Lower Respiratory Pathogens α Potential Lower Respiratory Pathogens α Potential Lower Respiratory Pathogens α Potential Lower Respiratory Pathogens α
25th %ile 25th %ile 25th-75th %ile 25th-75th %ile 25th-75th %ile 75th %ile 75th %ile 75th %ile Total Total Total
Sample n Sample n 11 11 21 21 21 9 9 9 41 41 41
Pathogenic bacteria n (%) Pathogenic bacteria n (%) 1 (9) 1 (9) 8 (38) 8 (38) 8 (38) 2 (22) 2 (22) 2 (22) 11 (27) 11 (27) 11 (27)
+ Virus PCR n (%) + Virus PCR n (%) 4 (36) 4 (36) 9 (43) 9 (43) 9 (43) 2 (22) 2 (22) 2 (22) 15 (37) 15 (37) 15 (37)
+ Bacteria/viruses + Bacteria/viruses 0 0 5 (24) ** 5 (24) ** 5 (24) ** 0 0 0 5 (12) 5 (12) 5 (12)
Lipid Laden Macrophage Index (range 0-5) Lipid Laden Macrophage Index (range 0-5) Lipid Laden Macrophage Index (range 0-5) Lipid Laden Macrophage Index (range 0-5) Lipid Laden Macrophage Index (range 0-5) Lipid Laden Macrophage Index (range 0-5) Lipid Laden Macrophage Index (range 0-5) Lipid Laden Macrophage Index (range 0-5) Lipid Laden Macrophage Index (range 0-5) Lipid Laden Macrophage Index (range 0-5) Lipid Laden Macrophage Index (range 0-5) Lipid Laden Macrophage Index (range 0-5) Lipid Laden Macrophage Index (range 0-5)
Median 0 ± 0 0 ± 0 0 ± 0 0 ± 0 0 ± 0 0 ± 0 0 ± 3 0 ± 3 0 ± 3 0 ± 0 0 ± 0 0 ± 0
References 19,23; isolated eosinophilia ≥ 1% eosinophils, and < 6% neutrophils; isolated neutrophilia ≥ 6% neutrophils and 0% eosinophils; mixed granulocytic ≥ 6% neutrophils and ≥ 1% eosinophils; pauci-granulocytic < 6% neutrophils and 0% eosinophils; Ϯ p = .04; α bacteria are Streptococcus pneumoniae, Hemophilus influenzae, and Moraxella catarrhalis; viruses are Enteroviradae/HRV, Human metapneumovirus, and Parainfluenza II; ** p = .05. *References 19,23; isolated eosinophilia ≥ 1% eosinophils, and < 6% neutrophils; isolated neutrophilia ≥ 6% neutrophils and 0% eosinophils; mixed granulocytic ≥ 6% neutrophils and ≥ 1% eosinophils; pauci-granulocytic < 6% neutrophils and 0% eosinophils; Ϯ p = .04; α bacteria are Streptococcus pneumoniae, Hemophilus influenzae, and Moraxella catarrhalis; viruses are Enteroviradae/HRV, Human metapneumovirus, and Parainfluenza II; ** p = .05. *References 19,23; isolated eosinophilia ≥ 1% eosinophils, and < 6% neutrophils; isolated neutrophilia ≥ 6% neutrophils and 0% eosinophils; mixed granulocytic ≥ 6% neutrophils and ≥ 1% eosinophils; pauci-granulocytic < 6% neutrophils and 0% eosinophils; Ϯ p = .04; α bacteria are Streptococcus pneumoniae, Hemophilus influenzae, and Moraxella catarrhalis; viruses are Enteroviradae/HRV, Human metapneumovirus, and Parainfluenza II; ** p = .05. *References 19,23; isolated eosinophilia ≥ 1% eosinophils, and < 6% neutrophils; isolated neutrophilia ≥ 6% neutrophils and 0% eosinophils; mixed granulocytic ≥ 6% neutrophils and ≥ 1% eosinophils; pauci-granulocytic < 6% neutrophils and 0% eosinophils; Ϯ p = .04; α bacteria are Streptococcus pneumoniae, Hemophilus influenzae, and Moraxella catarrhalis; viruses are Enteroviradae/HRV, Human metapneumovirus, and Parainfluenza II; ** p = .05. *References 19,23; isolated eosinophilia ≥ 1% eosinophils, and < 6% neutrophils; isolated neutrophilia ≥ 6% neutrophils and 0% eosinophils; mixed granulocytic ≥ 6% neutrophils and ≥ 1% eosinophils; pauci-granulocytic < 6% neutrophils and 0% eosinophils; Ϯ p = .04; α bacteria are Streptococcus pneumoniae, Hemophilus influenzae, and Moraxella catarrhalis; viruses are Enteroviradae/HRV, Human metapneumovirus, and Parainfluenza II; ** p = .05. *References 19,23; isolated eosinophilia ≥ 1% eosinophils, and < 6% neutrophils; isolated neutrophilia ≥ 6% neutrophils and 0% eosinophils; mixed granulocytic ≥ 6% neutrophils and ≥ 1% eosinophils; pauci-granulocytic < 6% neutrophils and 0% eosinophils; Ϯ p = .04; α bacteria are Streptococcus pneumoniae, Hemophilus influenzae, and Moraxella catarrhalis; viruses are Enteroviradae/HRV, Human metapneumovirus, and Parainfluenza II; ** p = .05. *References 19,23; isolated eosinophilia ≥ 1% eosinophils, and < 6% neutrophils; isolated neutrophilia ≥ 6% neutrophils and 0% eosinophils; mixed granulocytic ≥ 6% neutrophils and ≥ 1% eosinophils; pauci-granulocytic < 6% neutrophils and 0% eosinophils; Ϯ p = .04; α bacteria are Streptococcus pneumoniae, Hemophilus influenzae, and Moraxella catarrhalis; viruses are Enteroviradae/HRV, Human metapneumovirus, and Parainfluenza II; ** p = .05. *References 19,23; isolated eosinophilia ≥ 1% eosinophils, and < 6% neutrophils; isolated neutrophilia ≥ 6% neutrophils and 0% eosinophils; mixed granulocytic ≥ 6% neutrophils and ≥ 1% eosinophils; pauci-granulocytic < 6% neutrophils and 0% eosinophils; Ϯ p = .04; α bacteria are Streptococcus pneumoniae, Hemophilus influenzae, and Moraxella catarrhalis; viruses are Enteroviradae/HRV, Human metapneumovirus, and Parainfluenza II; ** p = .05. *References 19,23; isolated eosinophilia ≥ 1% eosinophils, and < 6% neutrophils; isolated neutrophilia ≥ 6% neutrophils and 0% eosinophils; mixed granulocytic ≥ 6% neutrophils and ≥ 1% eosinophils; pauci-granulocytic < 6% neutrophils and 0% eosinophils; Ϯ p = .04; α bacteria are Streptococcus pneumoniae, Hemophilus influenzae, and Moraxella catarrhalis; viruses are Enteroviradae/HRV, Human metapneumovirus, and Parainfluenza II; ** p = .05. *References 19,23; isolated eosinophilia ≥ 1% eosinophils, and < 6% neutrophils; isolated neutrophilia ≥ 6% neutrophils and 0% eosinophils; mixed granulocytic ≥ 6% neutrophils and ≥ 1% eosinophils; pauci-granulocytic < 6% neutrophils and 0% eosinophils; Ϯ p = .04; α bacteria are Streptococcus pneumoniae, Hemophilus influenzae, and Moraxella catarrhalis; viruses are Enteroviradae/HRV, Human metapneumovirus, and Parainfluenza II; ** p = .05. *References 19,23; isolated eosinophilia ≥ 1% eosinophils, and < 6% neutrophils; isolated neutrophilia ≥ 6% neutrophils and 0% eosinophils; mixed granulocytic ≥ 6% neutrophils and ≥ 1% eosinophils; pauci-granulocytic < 6% neutrophils and 0% eosinophils; Ϯ p = .04; α bacteria are Streptococcus pneumoniae, Hemophilus influenzae, and Moraxella catarrhalis; viruses are Enteroviradae/HRV, Human metapneumovirus, and Parainfluenza II; ** p = .05. *References 19,23; isolated eosinophilia ≥ 1% eosinophils, and < 6% neutrophils; isolated neutrophilia ≥ 6% neutrophils and 0% eosinophils; mixed granulocytic ≥ 6% neutrophils and ≥ 1% eosinophils; pauci-granulocytic < 6% neutrophils and 0% eosinophils; Ϯ p = .04; α bacteria are Streptococcus pneumoniae, Hemophilus influenzae, and Moraxella catarrhalis; viruses are Enteroviradae/HRV, Human metapneumovirus, and Parainfluenza II; ** p = .05. *References 19,23; isolated eosinophilia ≥ 1% eosinophils, and < 6% neutrophils; isolated neutrophilia ≥ 6% neutrophils and 0% eosinophils; mixed granulocytic ≥ 6% neutrophils and ≥ 1% eosinophils; pauci-granulocytic < 6% neutrophils and 0% eosinophils; Ϯ p = .04; α bacteria are Streptococcus pneumoniae, Hemophilus influenzae, and Moraxella catarrhalis; viruses are Enteroviradae/HRV, Human metapneumovirus, and Parainfluenza II; ** p = .05.