References
1.Kauczor H-U, Ebert M, Kreitner K-F, et al. Imaging of the lungs using
3He MRI: Preliminary clinical experience in 18 patients with and without
lung disease. J Magn Reson Imaging 1997; 7:538-543.
2.de Lange EE, Mugler JP 3rd, Brookman JR, Knight-Scott J, Truwit JD,
Teates CD, Daniel TM, Bogorad PL, Cates GD. Lung air spaces: MR imaging
evaluation with hyperpolarized 3He gas.Radiology 1999; 210:851-7.
3. de Lange EE, Altes TA, Patrie JT, Gaare JD, Knake JJ, Mugler III JP,
Platts-Mills TA. Evaluation of asthma with hyperpolarized helium-3 MRI:
Correlation with clinical severity and spirometry. Chest 2006;
130: 1055-1062.
4. de Lange EE, Altes TA, Patrie JT, et al. The variability of regional
airflow obstruction within the lungs of patients with asthma: assessment
with hyperpolarized helium-3 magnetic resonance imaging. J Allergy
Clin Immunol 2007; 119:1072-78.
5. Svenningsen S, Kirby M, Starr D, Coxson HO, Paterson NAM, McCormack
DG, Parraga G. What are ventilation defects in asthma? Thorax2014; 69:63-71.
6.de Lange EE, Altes TA, Patrie JT et al, Changes in regional airflow
obstruction over time in the lungs of patients with asthma: evaluation
with 3-He MR imaging. Radiology 2009; 250: 567-75.
7. Samee S, Altes T, Powers P, et al. Imaging the lungs in asthmatic
patients by using hyperpolarized helium-3 magnetic resonance: Assessment
of response to methacholine and exercise challenge. J Allery Clin
Immunol 2003; 111: 1205-1211.
8. Costello S, Kirby M, Makysm GN, McCormack DG, Paterson NAM, Parraga
G. Regional pulmonary response to a methacholine challenge using
hyperpolarized 3He magnetic resonance imaging. Respirology 2012;
17:1237-1246.
9. Kruger SJ, Niles DJ, Dardzinski B, et al. Hyperpolarized helium-3 MRI
of exercise-induced bronchoconstriction and during challenge and
therapy. J Magn Reson Imaging 2014; 39:1230-1237.
10. Fain SB, Gonzalez-Fernandez G, Peterson ET, Evans MD, Sorkness RL,
Jarjour NN, Busse WW, Kuhlman JE. Evaluation of structure-function
relationships in asthma using multi-detector CT and hyperpolarized He-3
MRI. Acad Radiol 2008; 15 (6): 753-62.
11.Altes TA. Mugler III JP, Ruppert K, Tustison NJ, Gersbach J,
Szentpetery S, Meyer CH, de Lange EE, Teague WG. Clinical correlates of
lung ventilation defects in asthmatic children. J Allergy Clin
Immunol 2016; 137: 789-96.
12. Mummy DG, Kruger SJ, Zha W, Sorkness RL, Jarjour NN, Schiebler ML,
Denlinger LC, Evans MD, Fain SB. Ventilation defect percent in helium-3
magnetic resonance imaging as a biomarker of severe outcomes in asthma.J Allergy Clin Immunol 2018; 141: 1140-1141.
13. Marozkina NV, Wang XQ, Stsiapura V, Fitzpatrick A, Carraro S,
Hawkins GA, Bleecker E, Meyers D, Jarjour N, Fain SB, Wenzel S, Busse W,
Castro M, Panettieri RA Jr, Moore W, Lewis SJ, Palmer LA, Altes T, De
Lange EE, Erzurum S, Teague WG, Gaston B. Phenotype of asthmatics with
increased airway S-nitrosoglutathione activity. Eur Respir J 2015; 45:
87-97.
14. Svenningsen S, Eddy RL, Lim HF, Cox PG, Nair P, Parraga G. Sputum
eosinophilia and magnetic resonance imaging ventilation heterogeneity in
severe asthma. Am J Respir Crit Care Med 2018; 197: 876-884.
15. Dunican EM, Elicker BM, Gierada DS, Nagle SK, Schiebler ML, Newell
JD, Raymond WW, Lachowicz-Scroggins ME, Di Maio S, Hoffman EA, Castro M,
Fain SB, Jarjour NN, Israel E, Levy BD, Erzurum SC, Wenzel SC, Meyers
DA, Bleecker ER, Phillips BR, Mauger DT, Gordon ED, Woodruff PG, Peters
MC, Fahy JV. Mucus plugs in patients with asthma linked to eosinophilia
and airflow obstruction. J Clin Invest 2018; 128: 997-1009.
16. Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore
WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone
AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness
RL, Gaston BM, Erzurum SC, Comhair SAA, Ross EM, Zein J, DeBoer MD,
Irani AM, Israel E, Levy B, Cardet JC, Phipatanakul W, Gaffin JM,
Holguin F, Fajt ML, Aujla SH. Mauger DT, Jarjour NN. Baseline features
of the Severe Asthma Research Program (SARP III) Cohort: Differences
with age. J Allergy Clin Immunol in Practice 2018; 6 (2):545-54.
17. Global Initiative for Asthma: Diagnosis and Management of
Difficult-to-Treat and Severe Asthma 2019; https://
ginaasthma.org/severeasthma. Last accessed August 3rd2020.
18. Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk P, Adcock
IM, Bateman E, Bel E, Bleecker E, Boulet LP, Brightling C, Chanez P,
Dahlen SE, Djukanovic R, Frey U, Gaga M, Gibson P, Hamid Q, Jarjour N,
Mauad T, Sorkness R, Teague WG. International ERS/ATS Consensus
Definition, Mechanisms, Evaluation and Treatment of Severe Asthma.Eur Respir J 2014; 43 (2): 343-73.
19. Teague WG. Lawrence MG, Shirley DT, Garrod AS, Early SV, Payne JB,
Wisniewski JA, Heymann PW, Daniero JJ, Steinke JW, Froh DK, Braciale TJ,
Ellwood M, Harris D, Borish L. Lung lavage granulocyte patterns and
clinical phenotypes in children with severe, therapy-resistant asthma.J Allergy Clin Immunol Pract 2019; 7(6): 1803-1812.
20. Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values
from a sample of the general U.S. population. Am J Respir Crit
Care Med 1999; 159: 179-187.
21.Tustison NJ, Avants BB, Flors L, Altes TA, de Lange EE, Mugler JP
3rd, Gee JC. Ventilation-based segmentation of the lungs using
hyperpolarized (3) He MRI. J Magn Reson Imaging 2011; 34: 831-41.
22. Wisniewski JA, Muehling LM, Eccles JD, Agrawal R, Capaldo BJ,
Shirley DA, Patrie JT, Workman L, Lawrence MG, Teague WG, Woodfolk JA.
TH1 signatures are present in the lower airways of children with severe
asthma, regardless of allergic status. J Allergy Clin Immunol 2018;141
(6): 2048-2060.
23.de Blic J, Midulla F, Barbato A, Clement A, Dab I, Eber E, et al, for
the ERS Task Force on Bronchoalveolar Lavage in Children. Eur
Respir J 2000; 15:217-31.
24. Thomen RP, Sheshadri A, Quirk JD, Kozlowski J, Ellison HD,
Szczesniak RD, Castro M, Woods JC. Regional ventilation changes in
severe asthma after bronchial thermoplasty with 3He MR imaging and CT.Radiology 2015; 274: 250-259.