Results
Sixty children had detailed characterizations with MRs, including 22 who
underwent diagnostic bronchoscopy. The mean sample age was 9.9 ± 3.9
years (Table I). Most were male (63%), 1/2 reported non-white
racial/ethnic backgrounds. Seventy-five % had cACT/ACT scores ≤ 19,
51% had ≥ 1 asthma-related hospital admissions in the past year. More
than 84% reported treatment with ≥ 2 asthma controller medications,
50% with ICS doses ≥ 800 mcg/day fluticasone equivalents. A pre-BD
FEV1/FVC % < 90%, was found in 47%.
Increased serum IgE to ≥ 1 allergens was detected in 80%, and 60% were
sensitized to ≥ 4 allergens. Eosinophilia, defined by ≥ 300
eosinophils/ul blood, was present in 50%.