Hyperpolarized Helium-3 Lung MRI Procedures
Children underwent a standard imaging protocol with safety monitoring
under IND 57866. Images were obtained without sedation using a 1.5-T
commercial whole-body scanner (Avanto, Siemens Medical Solutions,
Malvern PA) and either a flexible, vest-shaped chest radio frequency
(RF) coil (Clinical MR Solutions, Brookfield, WI) or a fixed geometry RF
coil (Rapid Biomedical, Rimpar, Germany) tuned to the He-3 resonant
frequency. Details of the MR acquisition procedures have been published
previously 11 and are described in detail in the
E-Supplement methods.