Results
Sixty children had detailed characterizations with MRs, including 22 who underwent diagnostic bronchoscopy. The mean sample age was 9.9 ± 3.9 years (Table I). Most were male (63%), 1/2 reported non-white racial/ethnic backgrounds. Seventy-five % had cACT/ACT scores ≤ 19, 51% had ≥ 1 asthma-related hospital admissions in the past year. More than 84% reported treatment with ≥ 2 asthma controller medications, 50% with ICS doses ≥ 800 mcg/day fluticasone equivalents. A pre-BD FEV­1­/FVC % < 90%, was found in 47%. Increased serum IgE to ≥ 1 allergens was detected in 80%, and 60% were sensitized to ≥ 4 allergens. Eosinophilia, defined by ≥ 300 eosinophils/ul blood, was present in 50%.