|
Study Cohort (No.=90) |
Study Cohort |
Study
Cohort |
P value
|
|
|
Significant QTc Prolongation |
Significant QTc
Prolongation |
|
|
|
No (No.=48) |
Yes (No.42) |
|
Male, % |
55 (61) |
26 (60) |
27 (61) |
0.83 |
Age, mean (SD) |
67 ± 11 |
67 ± 12 |
67 ± 11 |
0.91 |
BMI, mean (SD), kg/m2 |
30 ± 5 |
29 ± 4 |
30 ± 5 |
0.44 |
Atrial flutter |
7 (8) |
5 (11) |
2 (4) |
0.25 |
Heart Rate in AF, mean (SD), bpm |
80 ± 20 |
78 ± 21 |
82 ± 20 |
0.56 |
Ischemic Heart Disease, % |
19 (21) |
8 (16) |
12 (27) |
0.30 |
CHF, % |
30 (36) |
12 (29) |
18 (43) |
0.25 |
TEE, % |
63 (70) |
31 (63) |
32 (76) |
0.67 |
EF, mean (SD), % |
52 ± 12 |
54 ± 12 |
49 ± 14 |
0.11 |
LA size, mean (SD), cm |
4.5 ± 0.4 |
4.5 ± 0.5 |
4.4 ± 1 |
0.64 |
Mitral regurgitation, % |
56 (62) |
23 (48) |
33 (79) |
0.049 |
Mitral stenosis, % |
14 (15) |
7 (15) |
7 (17) |
0.86 |
Aortic stenosis, % |
12 (13) |
6 (14) |
6 (15) |
0.87 |
SPAP, mean (SD), mmHg |
34 ± 8 |
34 ± 8 |
35 ± 7 |
0.75 |
Diabetes, % |
25 (28) |
9 (19) |
16 (36) |
0.093 |
Hypertension, % |
60 (67) |
29 (67) |
30 (68) |
0.83 |
Renal disease, % |
21 (23) |
10 (24) |
11 (25) |
0.85 |
CHA2DS2VASc, mean (SD) |
3.5 ± 1.5 |
3.3
± 1.6 |
3.7 ± 1.7 |
0.32 |
ICD/CRTD, % |
2 (2) |
None |
2 (4) |
0.49 |
Pacemaker |
11 (12) |
5 (11) |
6 (15) |
0.74 |
ACE Inhibitor or ARB, % |
47 (52) |
22 (46) |
25 (60) |
0.64 |
Aldosterone, % |
10 (11) |
4 (9) |
6 (15) |
0.74 |
Beta-blocker, % |
67 (74) |
30 (63) |
37 (88) |
0.04 |
Calcium channel blocker, % |
25 (28) |
12 (26) |
13 (29) |
0.81 |
Digitalis, % |
6 (7) |
2 (4) |
4 (9) |
0.67 |
Amiodarone, % |
60 (67) |
30 (63) |
30 (69) |
0.83 |
Flecainide, % |
20 (22) |
10 (21) |
10 (23) |
0.79 |
Propafenone, % |
5 (6) |
4 (9) |
1 (2) |
0.36 |
Statins, % |
39 (43) |
21 (46) |
18 (42) |
0.56 |
NOAC, % |
66 (73) |
33 (69) |
33 (76) |
0.47 |
Warfarin, % |
24 (27) |
14 (30) |
10 (23) |
0.41 |
Creatinine, mean (SD), mg/dl |
1 ± 0.3 |
1 ±0.3 |
0.9 ± 0.3 |
0.32 |
K , mean (SD), mg/dl |
4.3 ± 0.4 |
4.3 ± 0.4 |
4.3 ± 0.4 |
0.73 |
Na , mean (SD), mg/dl |
140 ± 4 |
140 ± 3 |
140 ± 2 |
0.49 |
Mg , mean (SD), mg/dl |
2 ± 0.4 |
2± 0.2 |
2 ± 0.4 |
0.94 |