Figure 1: Left Atrial Strain on Echocardiography in Patients on
Ibrutinib with and without Atrial Fibrillation.
A) Apical 2-chamber echocardiographic window with an LA strain contour
for an adult male on ibrutinib therapy, who did not develop IRAF. B) LA
strain tracing of the patient in panel A) demonstrating preserved PALS
and PACS. Values represent population mean PALS and PACS with standard
deviation and the number of patients on ibrutinib who did not develop
IRAF. C) Apical 4-chamber echocardiographic window with an LA strain
contour for an adult male on ibrutinib who developed IRAF. D) LA strain
tracing of the patient in panel C) demonstrating decreased PALS and
PACS. Mean values and standard deviation represent all patients on
ibrutinib who developed AF. Notably, LA strain tracing demonstrates a
loss of well-defined contractile function.