Figure 1: Left Atrial Strain on Echocardiography in Patients on Ibrutinib with and without Atrial Fibrillation.
A) Apical 2-chamber echocardiographic window with an LA strain contour for an adult male on ibrutinib therapy, who did not develop IRAF. B) LA strain tracing of the patient in panel A) demonstrating preserved PALS and PACS. Values represent population mean PALS and PACS with standard deviation and the number of patients on ibrutinib who did not develop IRAF. C) Apical 4-chamber echocardiographic window with an LA strain contour for an adult male on ibrutinib who developed IRAF. D) LA strain tracing of the patient in panel C) demonstrating decreased PALS and PACS. Mean values and standard deviation represent all patients on ibrutinib who developed AF. Notably, LA strain tracing demonstrates a loss of well-defined contractile function.