On multivariate regression modeling, age was significantly associated with IRAF when examined in pairs with ibrutinib dose, E/e’, PALS, PACS and conduit strain. PALS was significantly associated with IRAF when evaluated in pairs with ibrutinib dose and E/e’, but not with age. PACS was significantly associated with IRAF when evaluated in pairs with ibrutinib dose, E/e’ and with age, suggesting an age-independent association of PACS and IRAF. PALS: peak atrial longitudinal strain; PACS: peak atrial contraction strain.