Transthoracic Echocardiography
Echocardiographic measurements were obtained according to the American
Society of Echocardiography guidelines [12] on GE or Phillips
machines. Two blinded reviewers retrospectively analyzed the
transthoracic echocardiograms of all patients prior to ibrutinib
treatment, obtaining measures of right atrial pressure, right
ventricular size (RV size), right ventricular fractional area change,
right ventricular systolic pressure, tricuspid regurgitation maximum
velocity (TR Vmax), TAPSE, left atrial indexed volume (LAVI), mitral E
and A velocity, mitral E/e’, diastolic dysfunction, valvular disease,
left ventricular ejection fraction (LVEF) and left ventricular global
longitudinal strain (LV GLS). RV size was measured as RV basal diameter
at end diastole in the apical 4 chamber view. LAVI was measured using
the biplane area-length method. Valvular disease was noted if patients
had moderate or severe mitral stenosis, mitral regurgitation, aortic
stenosis or aortic regurgitation.