Multivariate Regression
Age, ibrutinib dose, E/e’, PALS, PACS, and conduit strain were analyzed as pairs on Cox regression modeling given the low number of events. On multivariate regression modeling of age and ibrutinib, age and E/e’, age and PALS, and age and conduit strain, only age remained significant for association with IRAF. When age and PACS were evaluated, both remained significant for association with IRAF (p = 0.002 for age, p = 0.04 for PACS). On multivariate regression analysis of ibrutinib dose and PALS, and ibrutinib dose and PACS, both PALS and PACS significant for association with IRAF (p = 0.008 and p = 0.05, respectively). Additional multivariate regression analyses are shown in Table 4 .