Systematic reviews characterizing the inconsistency in outcome reporting
Thirty-nine systematic reviews characterizing the inconsistency in outcome reporting were identified (table S4)(45-83) including: 16 (41%) in benign gynaecology and subfertility, 12 (31%) in pregnancy and childbirth, 6 (15%) in newborn and neonatal health and five (13%) in oncology. Of these, 25 (64%) were included as part of COS development and the remaining 14 registered as standalone reviews (table S5). The variation in outcome reporting was considerable: for example, a review of intrauterine growth restriction trials identified 238 outcomes and a review of bladder pain syndrome trials identified only five.(46, 58)