Table 1: cAMP accumulation Table 1: cAMP accumulation Table 1: cAMP accumulation Table 1: cAMP accumulation Table 1: cAMP accumulation Table 1: cAMP accumulation
Ligand
pEC50 (M) ± SEM EC50 [nM]
Efficacy ± SEM
n
hGLP-2R hGLP-2(1-33) 9.7 ± 0.06 0.22 100 ± 2.5 10
hGLP-2(1-33,M10Y) 9.3 ± 0.06 0.56 96 ± 2.9 4
hGLP-2(3-33) 7.6 ± 0.28 27.5 11 ± 1.5 3
hGLP-2(3-33,M10Y) 7.5 ± 0.32 31.6 8.1 ± 1.2 7
hGLP-2 + 100 nM hGLP-2(3-33,M10Y) 8.9 ± 0.15 1.4 93 ± 12* 3
hGLP-2 + 1 µM hGLP-2(3-33,M10Y) 8.4 ± 0.20 4.3 78 ± 7.7* 3
hGLP-1R hGLP-1 11 ± 0.04 0.03 100 ± 1.3 9
hGLP-2(1-33) 7.0 ± 0.12 98 88 ± 6.0 7
hGLP-2(1-33,M10Y) 7.0 ± 0.13 112 100 ± 8.5 3
hGLP-2(3-33) N.A. N.A. N.A. 6
hGLP-2(3-33,M10Y) N.A. N.A. N.A. 6
hGLP-2 +100nM exedin(9-39) 6.1 ± 0.83 881 31 ± 8,9 5
hGLP-1 +1µM hGLP-2(3-33,M10Y) 10 ± 0.14 0.07 100 ± 5.5 3
hGLP-1 +100mM hGLP-2(3-33,M10Y) 10 ± 0.22 0.05 100 ± 8.8 3