|
Ligand
|
pEC50
(M) ± SEM
|
EC50
[nM]
|
Efficacy ± SEM
|
n
|
hGLP-2R |
hGLP-2(1-33) |
9.7 ± 0.06 |
0.22 |
100 ± 2.5 |
10 |
|
hGLP-2(1-33,M10Y) |
9.3 ± 0.06 |
0.56 |
96 ± 2.9 |
4 |
|
hGLP-2(3-33) |
7.6 ± 0.28 |
27.5 |
11 ± 1.5 |
3 |
|
hGLP-2(3-33,M10Y) |
7.5 ± 0.32 |
31.6 |
8.1 ± 1.2 |
7 |
|
hGLP-2 + 100 nM hGLP-2(3-33,M10Y) |
8.9 ± 0.15 |
1.4 |
93 ± 12* |
3 |
|
hGLP-2 + 1 µM hGLP-2(3-33,M10Y) |
8.4 ± 0.20 |
4.3 |
78 ± 7.7* |
3 |
hGLP-1R |
hGLP-1 |
11 ± 0.04 |
0.03 |
100 ± 1.3 |
9 |
|
hGLP-2(1-33) |
7.0 ± 0.12 |
98 |
88 ± 6.0 |
7 |
|
hGLP-2(1-33,M10Y) |
7.0 ± 0.13 |
112 |
100 ± 8.5 |
3 |
|
hGLP-2(3-33) |
N.A. |
N.A. |
N.A. |
6 |
|
hGLP-2(3-33,M10Y) |
N.A. |
N.A. |
N.A. |
6 |
|
hGLP-2 +100nM exedin(9-39) |
6.1 ± 0.83 |
881 |
31 ± 8,9 |
5 |
|
hGLP-1 +1µM hGLP-2(3-33,M10Y) |
10 ± 0.14 |
0.07 |
100 ± 5.5 |
3 |
|
hGLP-1 +100mM hGLP-2(3-33,M10Y) |
10 ± 0.22 |
0.05 |
100 ± 8.8 |
3 |