Maternal CVD risk factors according to the delivery of a SGA vs
AGA infant
Four studies reported on conventional CVD risk factors between women who
gave birth to SGA compared to AGA infants (table
1)7-10. Two studies classified SGA as birthweight
<10th population centile7,
10, one as birthweight <5th population
centile9 and the other as birthweight
<10th customised birthweight
centile8. Two studies were conducted on normotensive
women who gave birth to SGA infants8, 9. Four studies
compared SBP and DBP between women who gave birth to SGA infants
compared to those who gave birth to AGA infants. Of these, two studies
reported significantly higher SBP7, 9 and one study
reported significantly higher DBP7 among women who
gave birth to SGA infants after adjusting for confounding factors (table
1). BMI was reported in one study which found no significant difference
between the two comparison groups7. Three studies
compared lipids between the two study groups7, 9, 10.
Of these, two reported significantly higher serum
triglycerides9, 10 and one significantly higher LDL
cholesterol9 among women who gave birth to SGA infants
compared to those who gave birth to AGA infants (table 1). Blood glucose
was reported in three studies7, 9, 10 and insulin
level in one study9. All results on blood glucose and
insulin were not statistically significantly different between the two
comparison groups (table 1). Results of two studies were included in the
meta-analyses on SBP and DBP7, 8. The pooled analyses
did not show a significant difference in SBP or DBP between women who
gave birth to SGA compared to AGA infants (Supplementary figures 1 and
2).