Patients and clinical data
151 pregnancy women were excluded other liver disease, diagnosed as ICP
on the basis of skin pruritus in combination with abnormal liver
biochemistry indexes, e.g. TBA, ALT and AST, etc. In addition, 26
clinical features covering six main indicators of maternal and neonatal
data, including patient basic features (age, gestational age and body
mass index: BMI), ion concentration (K, Na, Cl, Ca, Mg, P), routine
blood test (the counts of white blood cell: WBC, red blood cell: RBC,
platelet: PLT, red blood cell distribution width.SD: RDW.SD), liver
function index (TBA, ALT, AST, total bilirubin: TBIL, direct bilirubin:
DBIL, indirect bilirubin: IDBIL), lipid index (CHOL, TG, high-density
lipoprotein: HDL, low-density lipoprotein: LDL,
uric
acid) and outcomes of pregnant women and newborns (birth weight and
bleeding amount), were recorded. Besides, we also recruited 1029
pregnancy women without ICP as negative controls.