Association of Valve Phenotype with Aortic Valve Replacement
Median clinical follow-up time was similar between groups (TAV: 6.2 (IQR 1.7-10.6) years vs. BAV: 6.4 (IQR 3.4-9.4) years, p=0.43). During the study period, 33 (19%) TAV patients and 22 (37%) BAV patients underwent surgical or transcatheter AVR (Figure 2 ). However, median time to AVR after initial diagnosis of AS was similar between cohorts at 2.7 (IQR 2.1-5.5) years in TAV patients and 3.3 (2.3-4.8) years in BAV patients (p=0.09). A stepwise Cox proportional hazards model revealed that BAV (HR: 1.73, 95% CI [1.00, 2.99], p=0.049) and baseline mean gradient (HR: 1.07, 95% CI [1.04, 1.10], p<0.001) were significantly associated with increased hazard of AVR (Table 4 ).