Factors Associated with Faster Hemodynamic Progression of Aortic
Stenosis
On univariate analysis, there was no significant difference between
aortic valve morphology and rapid progressor phenotype (Table
3 ). Factors that were significantly associated with rapid progression
were age (OR: 1.02, 95% CI [1.00, 1.04]; p=0.03) and baseline mean
gradient (OR: 1.04, 95% CI [1.00, 1.08]; p=0.04). On the other
hand, higher BMI was associated with slow progression (OR 0.95, 95% CI
[0.91, 0.99]; p=0.02). When comparing comorbidities between the
cohorts, BMI and presence of diabetes mellitus, chronic kidney disease,
or hypertension was not significant between rapid and slow progressors
and did not play a role in the progression of mean aortic gradient. On
multivariate analysis adjusted for age, BMI, and baseline mean gradient,
BAV was not significantly associated with rapid progression, p=0.7
(Table 3 ).