Factors Associated with Faster Hemodynamic Progression of Aortic Stenosis
On univariate analysis, there was no significant difference between aortic valve morphology and rapid progressor phenotype (Table 3 ). Factors that were significantly associated with rapid progression were age (OR: 1.02, 95% CI [1.00, 1.04]; p=0.03) and baseline mean gradient (OR: 1.04, 95% CI [1.00, 1.08]; p=0.04). On the other hand, higher BMI was associated with slow progression (OR 0.95, 95% CI [0.91, 0.99]; p=0.02). When comparing comorbidities between the cohorts, BMI and presence of diabetes mellitus, chronic kidney disease, or hypertension was not significant between rapid and slow progressors and did not play a role in the progression of mean aortic gradient. On multivariate analysis adjusted for age, BMI, and baseline mean gradient, BAV was not significantly associated with rapid progression, p=0.7 (Table 3 ).