Age, yrs, mean (SD)
Female sex, n (%)
|
56.5 (16.8)
48 (48.5)
|
61.3 (14.6)
34 (50.7)
|
46.4 (17.0)
14 (43.8)
|
<0.001
NS
|
Diagnosis
MPA, n (%)
GPA, n (%)
EGPA, n (%)
|
55 (55.6)
36 (36.4)
8 (8.1)
|
54 (80.6)
5 (7.5)
8 (11.9)
|
1 (3.1)
31 (96.9)
0 (0)
|
<0.001
<0.001
0.05
|
Time-course ANCA pattern
Monophasic, n (%)
Remitting, n (%)
Persistent, n (%)
Recurrent, n (%)
|
26 (26,3)
13 (13,1)
21 (21,2)
39 (39,4)
|
23 (34.3)
11 (16.4)
9 (13.4)
24 (35.8)
|
3 (9.4)
2 (6.3)
12 (37.5)
15 (46.9)
|
0.008
NS
0.006
NS
|
Clinical features
Constitutional symptoms, n (%)
Fever, n (%)
Anemia, n (%)
Microhaematuria, n (%)
Renal failure, n (%)
Alveolar haemorrhage, n (%)
Pulmonary infiltrates, n (%)
Pulmonary nodules, n (%)
Mononeuritis multiplex, n (%)
CNS involvement, n (%)
ENT involvement, n (%)
Purpura, n (%)
Arthritis, n (%)
Ocular involvement, n (%)
|
72 (72.7)
54 (54.5)
84 (84.8)
68 (68.7)
60 (60.6)
28 (28.3)
22 (22.2)
20 (20.2)
16 (16.2)
5 (5.1)
33 (33.3)
14 (14.1)
49 (49.5)
10 (10.1)
|
47 (70.1)
36 (53.7)
56 (83.6)
52 (77.6)
49 (73.1)
19 (28.4)
11 (16.4)
2 (3.0)
11 (16.4)
2 (3.0)
9 (13.4)
6 (9.0)
25 (37.3)
4 (6.0)
|
25 (78.1)
18 (56.3)
28 (87.5)
16 (50.0)
11 (34.4)
9 (28.1)
11 (34.4)
18 (56.3)
5 (15.6)
3 (9.4)
24 (75.0)
8 (25.0)
24 (75.0)
6 (18.8)
|
NS
NS
NS
0.006
<0.001
NS
0.04
<0.001
NS
NS
<0.001
0.03
<0.001
0.05
|
Treatment
Corticosteroids, n (%)
Cyclophosphamide, n (%)
Azathioprine, n (%)
Methotrexate, n (%)
Mycophenolic acid, n (%)
Plasmapheresis , n (%)
Rituximab, n (%)
|
99 (100)
78 (78.8)
39 (39.4)
12 (12.1)
20 (20.2)
17 (17.2)
32 (32.3)
|
67 (100)
51 (76.1)
24 (35.8)
2 (3.0)
17 (25.4)
15 (22.4)
19 (28.4)
|
32 (100)
27 (84.4)
15 (46.9)
10 (31.3)
3 (9.4)
2 (6.3)
13 (40.6)
|
NS
NS
NS
<0.001
NS
0.05
NS
|
Outcome
Follow-up, yrs, median (IQR)
Clinical relapsea, n (%)
Worsening renal function, n (%)
End-stage renal disease, n (%)
-ESRD at baseline, n (%)
-ESRD during follow-up, n (%)
Mortality, n (%)
Mortality related to vasculitis, n (%)
|
9.0 (9.22)
59 (59.6)
26 (26.3)
19 (19.2)
8 (8.1)
11 (11.1)
29 (29.3)
5 (5.1)
|
7.6 (7.3)
32 (47.8)
21 (31.3)
17 (25.4)
7 (10.4)
10 (14.9)
24 (35.8)
4 (6.0)
|
12.2 (9.8)
27 (84.4)
5 (15.6)
2 (6.3)
1 (3.1)
1 (3.1)
5 (15.6)
1 (3.1)
|
0.001
0.001
NS
0.02
NS
NS
0.04
NS
|