Statistical analysis
For human data, differences between groups were analysed using the Wilcoxon signed rank test. For mouse data, differences between two groups and between three groups were analysed using the Mann–WhitneyU test and Steel–Dwass test, respectively. When p-values less than 0.05, differences between means were considered to be statistically significant. All analyses and calculations were performed using JMP® Pro version 13.0.0 software (SAS Institute, Inc., Cary, NC, USA).