Statistical analysis
For mouse data, differences between two groups and between three groups
were analysed using the Mann–Whitney U test and Steel–Dwass
test, respectively. For human data, differences between groups were
analysed using the Wilcoxon signed rank test. When p-values less than
0.05, differences between means were considered to be statistically
significant. All analyses and calculations were performed using
JMP® Pro version 13.0.0 software (SAS Institute, Inc.,
Cary, NC, USA).