Statistical analysis
For mouse data, differences between two groups and between three groups were analysed using the Mann–Whitney U test and Steel–Dwass test, respectively. For human data, differences between groups were analysed using the Wilcoxon signed rank test. When p-values less than 0.05, differences between means were considered to be statistically significant. All analyses and calculations were performed using JMP® Pro version 13.0.0 software (SAS Institute, Inc., Cary, NC, USA).