Variables
|
All patients (n=105) | NYHA I (n=11) | NYHA II (n=54) |
NYHA III-IV (n=40)
|
P-value
|
LV functional parameters | LV functional parameters | LV functional parameters | LV functional parameters | LV functional parameters | LV functional parameters |
LVEDV index (ml/m2) | 126±39 | 144±49 | 125±37 | 123±38 | 0.27 |
LVESV index (ml/m2) | 92±32 | 102±42 | 89±29 | 93±34 | 0.51 |
LVEF (%) | 28±7 | 30±8 | 29±7 | 26±8 | 0.06 |
Mitral flow parameters | Mitral flow parameters | Mitral flow parameters | Mitral flow parameters | Mitral flow parameters | Mitral flow parameters |
E wave velocity (cm/s) | 77±21 | 71±15 | 76±22 | 80±23 | 0.45 |
E wave DT (ms) | 174±45 | 174±41 | 178±49 | 168±42 | 0.59 |
A wave velocity (cm/s) | 69±22 | 60±19 | 73±22 | 66±22 | 0.08 |
E/A ratio | 1.27±0.66 | 0.90±0.25 § | 1.16±0.57 | 1.42±0.80 | 0.04 |
Average E/E’ ratio | 13.4±5.6 | 11.4±3.1 § | 12.2±4.2 § | 15.5±7 | 0.007 |
GLS-LV (%) | -7.9±2.9 | -9.8±3.2 § | -8.3±2.6 § | -6.7±2.8 | 0.002 |
LA volume index (ml/m2) | 48±22 | 46±24 | 47±22 | 51±23 | 0.66 |
RV functional parameters | RV functional parameters | RV functional parameters | RV functional parameters | RV functional parameters | RV functional parameters |
RV basal diameter (mm) | 37±6 | 36±6 | 37±5 | 38±7 | 0.26 |
TAPSE (mm) | 18±4 | 19±3 § | 19±3 § | 16±4 | 0.002 |
S wave velocity (cm/s) | 10.6±2 | 11.2±1.5 | 11.2±1.7 § | 9.7±2.3 | 0.002 |
RV-FAC (%) | 34±10 | 34±7 | 36±8 | 32±11 | 0.06 |
Tricuspid flow parameters | Tricuspid flow parameters | Tricuspid flow parameters | Tricuspid flow parameters | Tricuspid flow parameters | Tricuspid flow parameters |
E wave velocity (cm/s) | 54±11 | 51±8 | 54±10 | 55±13 | 0.50 |
E wave DT (ms) | 176±38 | 184±22 | 176±37 | 175±43 | 0.76 |
A wave velocity (cm/s) | 48±12 | 55±10 § | 48±11 | 44±12 | 0.01 |
E/A ratio | 1.20±0.34 | 0.96±0.28 § | 1.18±0.34 | 1.30±0.31 | 0.01 |
GLS-RV (%) | -12±5 | -14.3±4.4 | -12.8±5 § | -10.3±4.6 | 0.01 |
RVFW-LS (%) | -15±7.9 | -19.3±6.3 § | -15.8±7.6 | -12.8±8.2 | 0.03 |
RA volume index (ml/m2) | 24 (19–35) | 23 (16–35) | 26 (20–35) | 24 (18–35) | 0.98 |
More than mild TR, n(%) | 20 (19%) | 2 (18%) | 6 (11%) | 12(30%) | 0.07 |
PASP (mm Hg) | 30 (22–39) | 30 (26–34) | 28 (22–34) | 32 (21–44) | 0.29 |
§ significant versus NYHA III-IV Continuous ata are expressed as mean ± standard deviation or median (interquartile range). Categorical data are expressed as number (percentage). Units of measurement are given in parentheses. n – number of patients; LV – left ventricle; EDV – end-diastolic volume; ESV – end-systolic volume; EF – ejection fraction; DT – deceleration time; GLS – global longitudinal strain; LA – left atrium; RV – right ventricle; FAC – fractional area change; TAPSE – tricuspid annular plane systolic excursion; FW-LS – free wall longitudinal strain; RA – right atrium; TR – tricuspid regurgitation; PASP – pulmonary artery systolic pressure Bolded p-values are statistically significant | § significant versus NYHA III-IV Continuous ata are expressed as mean ± standard deviation or median (interquartile range). Categorical data are expressed as number (percentage). Units of measurement are given in parentheses. n – number of patients; LV – left ventricle; EDV – end-diastolic volume; ESV – end-systolic volume; EF – ejection fraction; DT – deceleration time; GLS – global longitudinal strain; LA – left atrium; RV – right ventricle; FAC – fractional area change; TAPSE – tricuspid annular plane systolic excursion; FW-LS – free wall longitudinal strain; RA – right atrium; TR – tricuspid regurgitation; PASP – pulmonary artery systolic pressure Bolded p-values are statistically significant | § significant versus NYHA III-IV Continuous ata are expressed as mean ± standard deviation or median (interquartile range). Categorical data are expressed as number (percentage). Units of measurement are given in parentheses. n – number of patients; LV – left ventricle; EDV – end-diastolic volume; ESV – end-systolic volume; EF – ejection fraction; DT – deceleration time; GLS – global longitudinal strain; LA – left atrium; RV – right ventricle; FAC – fractional area change; TAPSE – tricuspid annular plane systolic excursion; FW-LS – free wall longitudinal strain; RA – right atrium; TR – tricuspid regurgitation; PASP – pulmonary artery systolic pressure Bolded p-values are statistically significant | § significant versus NYHA III-IV Continuous ata are expressed as mean ± standard deviation or median (interquartile range). Categorical data are expressed as number (percentage). Units of measurement are given in parentheses. n – number of patients; LV – left ventricle; EDV – end-diastolic volume; ESV – end-systolic volume; EF – ejection fraction; DT – deceleration time; GLS – global longitudinal strain; LA – left atrium; RV – right ventricle; FAC – fractional area change; TAPSE – tricuspid annular plane systolic excursion; FW-LS – free wall longitudinal strain; RA – right atrium; TR – tricuspid regurgitation; PASP – pulmonary artery systolic pressure Bolded p-values are statistically significant | § significant versus NYHA III-IV Continuous ata are expressed as mean ± standard deviation or median (interquartile range). Categorical data are expressed as number (percentage). Units of measurement are given in parentheses. n – number of patients; LV – left ventricle; EDV – end-diastolic volume; ESV – end-systolic volume; EF – ejection fraction; DT – deceleration time; GLS – global longitudinal strain; LA – left atrium; RV – right ventricle; FAC – fractional area change; TAPSE – tricuspid annular plane systolic excursion; FW-LS – free wall longitudinal strain; RA – right atrium; TR – tricuspid regurgitation; PASP – pulmonary artery systolic pressure Bolded p-values are statistically significant | § significant versus NYHA III-IV Continuous ata are expressed as mean ± standard deviation or median (interquartile range). Categorical data are expressed as number (percentage). Units of measurement are given in parentheses. n – number of patients; LV – left ventricle; EDV – end-diastolic volume; ESV – end-systolic volume; EF – ejection fraction; DT – deceleration time; GLS – global longitudinal strain; LA – left atrium; RV – right ventricle; FAC – fractional area change; TAPSE – tricuspid annular plane systolic excursion; FW-LS – free wall longitudinal strain; RA – right atrium; TR – tricuspid regurgitation; PASP – pulmonary artery systolic pressure Bolded p-values are statistically significant |