Limitations and Restrictions of AIT RWD Analyses
The results in real-world analyses summarized here have some limitations and restrictions, e.g. the validity of disease diagnoses (in most studies medication serves as a proxy to identify the disease) or the influence of OTC medication which is not included in prescription databases. Patients’ drug consumption behavior is not analyzed, the severity of the disease and patients’ symptom control is not known. The selection of control patients in the chosen matching process has a strong impact on the results. A detailed overview is given in Table S10 in the supplementary information.