Methods

We performed a literature search in PubMed for full-text publications dealing with retrospective cohort assessments of prescription databases in Europe, which investigated AIT products from the real-world perspective. We used the search profile ((desensitization, immunologic OR sublingual immunotherapy OR subcutaneous immunotherapy) AND ((retrospective database) OR (real world evidence) OR (medication adherence AND retrospective)) and included all respective publications until March 31,2022.
Data for long-term effectiveness in allergic rhinitis, allergic asthma, time to onset of asthma and medication adherence were summarized and evaluated.