Medication adherence
Seven RWE studies examined adherence to medication (14,15,17,20,23–25). Most assessments used different terms and adherence definitions, e.g. adherence, persistence, compliance, making direct comparisons difficult. Nevertheless, studies evaluating the recommended three-years’ time horizon for AIT showed that medication adherence decreased over the therapy years (14,15,17,20,23,24). Three studies showed that adherence and compliance were significantly higher with SCIT than with SLIT treatment (14,17,24). Results for days on therapy confirmed this result (14,17). One study contrasted these results with a higher persistence with SLIT than with SCIT (23) while another one showed comparable adherence to and persistence with SLIT and SCIT (20). For details see tables S5, S6, S7, S8 in supplementary information.