Progression of allergic rhinitis
Six of the RWE studies evaluating progression of grass pollen-, tree pollen- or house dust mite-allergic rhinitis showed that all investigated SCIT and SLIT preparations or preparation groups were significantly more effective compared to symptomatic treatment for up to 6 years follow-up (15,17–19,21,22). In another analysis, rhinitis prescriptions were significantly reduced during the years 1 and 4 to 7, when assessed cross-sectionally year by year (25).
Two assessments confirmed the effectiveness in children suffering from grass pollen-, tree pollen- and HDM-AR when being treated with different SCIT and SLIT preparations (15,17). Another study even showed a significantly higher effect for two grass pollen SLIT tablets in patients below the age of 18 compared to adults (21). Stronger reductions in AR prescriptions were shown across various AIT subgroups compared to Non-AIT (e.g. grass and tree pollen AIT, HDM AIT, children, adults, native allergens, allergoids, SCIT, SLIT drops and SLIT tablets for the 3rd year of the assessed period of 9 years (25). Whether these differences reached significance was not shown. For details, see tables S5, S6, S7, S8 in supplementary information.