Conclusion
Real-world data for AIT complement those from randomized controlled
trials. The RWE studies summarized in this review demonstrated the
effectiveness of AIT in hampering the progression of rhinitis and asthma
and onset of asthma for AIT with different allergens, AIT products, and
for different age groups in daily practice. Data for medication
adherence are more true-to-life when based on real-world data but due to
divergent adherence definitions there are no consistent results in the
different real-world assessments. Regulatory authorities are currently
developing standards for generating and assessing RWE data to support
regulatory decision-making for drug and biological products.