Figure 5 –Combinatorial use of small molecule enhancers has an additive effect on
genome titre. rAAV8 producing cells were treated 4 HPT with small
molecule enhancers of genome titre or left untreated. Cells were
harvested 72 HPT and measurements taken of viable cell density (VCD)
(A ), viability (B ), mean cell volume (C ), and
rAAV8 genome titre as a fold change with respect to untreated cells
(-/-/-) (D ). Data shown are the mean ± S.E.M. n = 3 independent
biological replicates. Data were analysed by one-way ANOVA followed by
post-hoc Holm-Šídák multiple comparisons test with respect to untreated
cells (-/-/-). * p < 0.05, ** p < 0.01, *** p
< 0.001, **** p < 0.0001.