Analyses of whole blood coagulation activity
Coagulation activity of whole blood was measured every 15 min using a
coagulation and platelet function analyser (Sonoclot)
(Sienco, Morrison, CO) as previously described22. The
Sonoclot signal typically describes coagulation parameters including
activated clotting time (ACT), which indicates the period up to the
start of fibrin formation, and clot rate, which indicates the slope of
fibrin gel formation that is affected by both the fibrinogen to fibrin
conversion and the amount of fibrinogen.