Details of Ethics Approval
The experimental protocol was approved by the Institutional Review Board for the Care of Animal Subjects of the National Defense Medical College (ethical approval number: #17032, 07/08/2017). All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.
Funding. This work was supported in part by JSPS KAKENHI (grant number 19K09760 (Y.Y., M.M., K.H., M.K., and K.T.) and AMED (grant numbers 18lk14030XXh0002 and 19lk1403022h0002 (M.K. and H.S.) from Japan Agency for Medical Research Development.