Coagulation variables and activity and plasma nitric oxide
levels
The plasma fibrinogen levels in RBC/PPP group gradually decreased but
was maintained over 110 mg/dL even at the end of the experiment because
PPP contained a certain amount of coagulation factors, including
fibrinogen (Figure 4A). In contrast, the plasma fibrinogen levels
continuously decreased and reached 20 mg/dL in both HbV and HES groups
(Figure 7A). The values of AT III in both HbV and HES groups were
significantly shorter than those in RBC/PPP group at 45
(p <0.05) and 60 min (p <0.01) (Figure
4B). Similarly, the PT was significantly lower in the HbV and HES groups
than in the RBC/PPP group at the end of the experiment
(p <0.01) (Figure 4C). Regarding APTT, the value beyond
30 min was set as reference because the value in over 75 sec could not
be measured in this analysis (Figure 4D).
Regarding coagulation activity, ACT was significantly prolonged in both
the HbV and HES groups at the end of experiment compared with that in
the RBC/PPP group (p <0.05) (Figure S3A). As for clot
rate, all three groups showed similar decreases in the clot rate with no
significant differences (Figure S3B). There were also no significant
differences in plasma NOx levels among the three groups
throughout the experiment, and HbV group showed no significant reduction
of NOx levels (Figure S3C).