Main Findings
This study developed a severe PPH model after caesarean section using
pregnant rabbits. Total haemorrhage was approximately at least 50 mL/kg
and led to severe PPH that became lethal within a few hours in the
absence of any fluid resuscitation. As a result, we established an
appropriate animal model requiring massive transfusion according to
actual clinical practice. Using the current PPH model, we demonstrated
that HbVs helped to maintain haemodynamics for severe PPH. The acute
prognosis was better than that achieved with administration of HES,
resulting in a drastic reduction of mortality.