Haemodynamic changes and rabbit survival
The rabbits developed postoperative severe anaemia (Hb concentration
<6 g/dL) that progressed to severe PPH in the first 30 min.
There were no significant differences in total haemorrhage volume, time
to severe PPH, and total bleeding time among the three groups (Table
S2). Although the HES group showed progressively decreased mean arterial
pressure (MAP) of less than 40 mmHg at the resuscitative phase, the HbV
and RBC/PPP groups maintained MAP above 50 mmHg during this period
(Figure 2A). The shock index was also gradually increased until two
times higher than that at baseline in the HES group, whereas it was only
increased to within 1.5 times higher than that at baseline in the
RBC/PPP and HbV groups (Figure 2B). Within 6 hours, all rabbits in the
HES group died, whereas all of the rabbits in the RBC/PPP group
survived, and 8 of the 10 rabbits in the HbV group survived. Regarding
overall survival, the prognosis of HbV group was significantly better
than that of HES group (p <0.01), whereas it was
significantly worse than that of RBC/PPP group (p =0.01) (Figure
3).