Human subjects
This study was approved by the Ethics Committee of the University
Hospital Germans Trias i Pujol and was performed in accordance
with the Declaration of Helsinki for Human Research. Written informed
consent was obtained from all participants. Muscle biopsies were
obtained from the biceps brachii of five patients with confirmed
DM1. For comparison, we included as controls non-DM1 patients of the
traumatology department, who needed to undergo minor surgeries. Patients
and controls were age and sex-matched. We recorded clinical data for
each DM1 patient, including MIRS, MRC, 6MWD and mRS, the latter rates
global disability and is mostly used for strokes, even though it can be
applied to other causes of neurological impairment.