Mode of transmission:
Genomic succession investigation of COVID-19 gives the evidence that about 88% similarities with 2 bat-derived (SARS) coronaviruses, signifying that the mammals are the for the most part have probable association flanked by COVID-19 with humans. Numerous reports have recommended that the transmission which is causative for spreading this infection is person-to-person transmission Mi, B et al (2020). This mode of transmission as Person-to-person transmission appears to be occurred mainly by means of the direct contact or may be all the way through the droplets spread by sneezing and coughing as of the infected person. But there is no transmission of the virus between mother and child either through placenta or via lactation in pregnant or lactating mothers. This is significant as the pregnant mothers are comparatively supplementary vulnerable to infection by means of pathogens of respiratory tract type of along with severe pneumonia Onder, G et al (2020). The infectious diseases can be transmitted from animal to the human and then further human to human transmission is also occurs. This transmission could be direct or indirect tin nature Yang, G et al (2020). But for SARS-COV2 we can explain this transmission is from animals to human (zoonotic) in nature due to the evaluation of the people working in animal market in Wuhan, China from where it actually spread Wu, Z et al (2020). The researchers are trying to find the reservoir host or the intermediate carrier which is actually the cause of spread to human. But, to date, we are unable to find the reservoirs other than mammals along with those of birds Jiang, F et al (2020).The binding of the receptor uttered through the cells of the host is the foremost step of this infection subsequent to union through cell membrane. It is consistent that the epithelial cells of the lungs are considered to be the target as of virus Huang, X et al (2020). Therefore, it has been reported that the person- to- person transmissions as of the SARS-CoV mainly appears to be occur through the binding of spikes of the virus with receptors of the cell as (ACE2) angiotensin-converting enzyme 2 Jin, X et al (2020). Significantly, the succession of the receptor-binding COVID-19 domain related in the direction of the SARS-CoV. It also give the suggestion that entry and survival in the cell is via ACE2 receptors which facilitates its binding and also protect from harsh internal environment of body. And thus help in its survival in the body Mo, P et al (2020).