Ivermectin:
Ivermectin is a broad-spectrum, FDA-approved anti-helminthic drug. It causes hyperpolarization by binding to glutamate-gated chloride channels resulting in paralysis and death of the parasite. It acts through various other unknown mechanisms. Moreover, its anti-viral action is due to its interference with virus entry into the cell. In vitro study of the drugs showed that ~5000-fold reduction in viral load is done by the single dose of ivermectin within 48 hours in cell culture[11]. Clinical trials for the drug are ongoing. These trials aim to determine the efficacy profile, safety, and possible adverse reaction of the combination therapy for hydroxychloroquine and ivermectin in hospitalized patient[41]. However, in vivo and clinical studies needed for the individual therapy for ivermectin.