Ivermectin:
Ivermectin is a broad-spectrum, FDA-approved anti-helminthic drug. It
causes hyperpolarization by binding to glutamate-gated chloride channels
resulting in paralysis and death of the parasite. It acts through
various other unknown mechanisms. Moreover, its anti-viral action is due
to its interference with virus entry into the cell. In vitro study of
the drugs showed that ~5000-fold reduction in viral load
is done by the single dose of ivermectin within 48 hours in cell
culture[11]. Clinical trials for the drug are
ongoing. These trials aim to determine the efficacy profile, safety, and
possible adverse reaction of the combination therapy for
hydroxychloroquine and ivermectin in hospitalized
patient[41]. However, in vivo and clinical studies
needed for the individual therapy for ivermectin.