n=number of patients with corresponding evaluable pharmacokinetic
parameters.
Model is a linear mixed effects model of the log-transformed PK
parameters. Included in the model were treatment as a fixed factor and
patient as a random factor. The results were back transformed to get
adjusted geometric mean, geometric mean ratio, and 90% CI.
Abbreviations: AUCinf, area under the concentration-time
curve from time zero to infinity; AUClast, area under
the concentration-time curve from time zero to the last quantifiable
concentration; CI, confidence interval; Cmax, maximum
concentration; Geo-mean, geometric mean; PK, pharmacokinetic.