Pharmacokinetic Parameters Digoxin alone N=25 Digoxin alone N=25 Capmatinib + digoxin N=25 Capmatinib + digoxin N=25 Rosuvastatin alone N=24 Rosuvastatin alone N=24 Capmatinib + rosuvastatin N=24 Capmatinib + rosuvastatin N=24
n Geo-mean (Geo-CV%) n Geo-mean (Geo-CV%) n Geo-mean (Geo-CV%) n Geo-mean (Geo-CV%)
AUCinf, ng h/mL 9 25.3 (36.3) 12 34.1 (37.9) 21 78.2 (73.4) 22 159 (99.8)
AUClast, ng h/mL 25 14.6 (58.0) 25 23.8 (50.5) 24 71.0 (71.3) 24 144 (102.6)
Cmax, ng/mL 25 1.12 (57.9) 25 1.95 (56.8) 24 7.72 (73.4) 24 23.5 (85.5)
Tmax, ha
25
1.07 (0.500, 6.00)
25
1.00 (0.417, 4.08)
24
2.04 (0.500, 6.00])
24
1.55 (0.500, 9.93)
T1/2, h 9 47 (29.8) 12 61.4 (25.7) 21 22 (73.8) 22 21.4 (56.6)
CL/F, L/h 9 9.89 (36.3) 12 7.33 (37.9) 21 128 (73.4) 22 62.8 (99.8)
VZ/F, L 9 671 (16.5) 12 649 (22.3) 21 4060 (80.2) 22 1940 (105.1)