Conclusion
In conclusion, CJD was incurable, irreversible, and had the propensity to present atypically. It is vital to make an early and prompt diagnosis based on its clinical features due to its mortality and infectivity. In this case, the female patient’s clinical manifestations and the course of the disease were consistent with the diagnostic criteria of the disease. This patient has not undergone the lumbar puncture or the brain biopsy. However, the clinical diagnosis will help the family member prepare palliative care and improve the quality of the rest life of the patient. With the advent of advanced neuroimaging, the new RT-QuIC technology, the rate of misdiagnosis of CJD has reduced. However, it was still critical for the clinician to fully recognize this fatal neurodegenerative disease and differentiate it from other mimic diseases, especially in elderly patients, and avoid initiating inappropriate therapy.